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We now show that agents able to prevent indirectly induced bronchoconstriction (sodium cromoglycate, nedocromil sodium, and furosemide) reduce either the single-channel conductance or the open probability of this channel. The effects of these agents and the Ca2+ dependence of the channel are localized to the same surface, and we show that the channel possesses a specific divalent cation binding site, which responds to concentrations of Ca2+ found on the airway mucosal surface. No alteration of the single-channel properties of this channel were seen in cystic fibrosis epithelium. These data suggest a mechanism by which structurally diverse agents may influence asthma.<\/jats:p>","DOI":"10.1165\/ajrcmb.14.4.8600943","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T22:28:03Z","timestamp":1365028083000},"page":"380-387","source":"Crossref","is-referenced-by-count":28,"title":["Asthma Prophylaxis Agents Alter the Function of an Airway Epithelial Chloride Channel"],"prefix":"10.1093","volume":"14","author":[{"given":"E W","family":"Alton","sequence":"first","affiliation":[{"name":"Ion Transport Unit, Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Kingsleigh-Smith","sequence":"additional","affiliation":[{"name":"Ion Transport Unit, Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F M","family":"Munkonge","sequence":"additional","affiliation":[{"name":"Ion Transport Unit, Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S N","family":"Smith","sequence":"additional","affiliation":[{"name":"Ion Transport Unit, Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A R","family":"Lindsay","sequence":"additional","affiliation":[{"name":"Ion Transport Unit, Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D C","family":"Gruenert","sequence":"additional","affiliation":[{"name":"Ion Transport Unit, Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P K","family":"Jeffery","sequence":"additional","affiliation":[{"name":"Ion Transport Unit, Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Norris","sequence":"additional","affiliation":[{"name":"Ion Transport Unit, Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D M","family":"Geddes","sequence":"additional","affiliation":[{"name":"Ion Transport Unit, Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Williams","sequence":"additional","affiliation":[{"name":"Ion Transport Unit, Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1996,4,1]]},"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/14\/4\/380\/67384939\/ajrcmb_14_4_380.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/14\/4\/380\/67384939\/ajrcmb_14_4_380.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:13:42Z","timestamp":1773800022000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/14\/4\/380\/8526770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1996,4,1]]},"published-print":{"date-parts":[[1996,4,1]]}},"URL":"https:\/\/doi.org\/10.1165\/ajrcmb.14.4.8600943","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1996,4]]},"published":{"date-parts":[[1996,4,1]]}}}