{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:11:05Z","timestamp":1784700665463,"version":"3.55.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1996,6,1]],"date-time":"1996-06-01T00:00:00Z","timestamp":833587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Interleukin 6 (IL-6) is a multifunctional inflammatory cytokine whose abnormal production has been implicated in a variety of diseases. Our previous study demonstrated that exudative pleural effusions contain a large amount of IL-6, and the levels of IL-6 in pleural effusion have diagnostic and pathophysiologic values. Although IL-6 is produced by a variety of cells, the origin of IL-6 in pleural effusion has not been determined clearly. We hypothesized that pleural mesothelial cells (PMCs) are an important source of IL-6 in pleural diseases. In this study, we tried to demonstrate whether PMCs could produce IL-6 and to characterize the modulation of its production. PMCs were established from patients with nonmalignant pleural effusion. Immunoreactive IL-6 could be detected in cultured supernatants of all PMCs from five patients, and all IL-6 detected in the supernatants were biologically active. IL-6 production was augmented by the addition of interleukin 1 \u03b1 (IL-1 \u03b1) in a dose-dependent manner and suppressed by dexamethasone. Expression of IL-6 mRNA was spontaneously observed and was increased by IL-1 \u03b1. PMCs also expressed mRNA for IL-6 receptors gp80 and gpl30. Spontaneous cell growth and DNA synthesis of PMCs were inhibited by the addition of a neutralizing anti-IL-6 monoclonal antibody and were promoted by the addition of IL-6 to the culture. These results suggest that IL-6 is an autocrine growth factor for PMCs.<\/jats:p>","DOI":"10.1165\/ajrcmb.14.6.8652179","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T22:28:17Z","timestamp":1365028097000},"page":"508-515","source":"Crossref","is-referenced-by-count":30,"title":["Interleukin 6 is an Autocrine Growth Factor for Normal Human Pleural Mesothelial Cells"],"prefix":"10.1093","volume":"14","author":[{"given":"S","family":"Fujino","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine, Ehime University, School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Ehime University, School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Kohno","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Ehime University, School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Hiwada","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Ehime University, School of Medicine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1996,6,1]]},"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/14\/6\/508\/67385035\/ajrcmb_14_6_508.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/14\/6\/508\/67385035\/ajrcmb_14_6_508.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:15:00Z","timestamp":1773800100000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/14\/6\/508\/8526800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1996,6,1]]},"published-print":{"date-parts":[[1996,6,1]]}},"URL":"https:\/\/doi.org\/10.1165\/ajrcmb.14.6.8652179","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1996,6]]},"published":{"date-parts":[[1996,6,1]]}}}