{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:05:46Z","timestamp":1791219946176,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1996,10,1]],"date-time":"1996-10-01T00:00:00Z","timestamp":844128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acid aspiration is a serious complication of anesthesia and other forms of unconsciousness that can result in the adult respiratory distress syndrome (ARDS), which continues to have a very high mortality despite our current therapeutic interventions. This type of injury damages the alveolar epithelium, principally alveolar type I cells, and requires proliferation of alveolar type II cells to restore gas exchange units. Since keratinocyte growth factor (KGF) has been shown to be a potent mitogen for alveolar type II cells, we evaluated whether intrabronchial administration of KGF would minimize lung injury due to the unilateral instillation of 0.1 N hydrochloric acid (HCl). Rats were pretreated or post-treated by intrabronchial instillation of KGF (5 mg\/kg) into the left lung before HCl instillation. All rats receiving KGF at 48 or 72 h before HCl instillation survived for the 7-day observation period, whereas the mortality rate for those receiving HCl alone or saline followed by HCl was 31% and 33%, respectively. Pretreatment with KGF at 72 h but not at 24 or 48 h considerably ameliorated morphologic damage produced by HCl. Inflammatory cells in bronchoalveolar lavage were markedly decreased 3 and 7 days after HCl instillation by the 72-h KGF pretreatment. Pretreatment with KGF at 72 h also attenuated the reduction of total lung capacity, decreased the \u03b11(I) procollagen mRNA levels, and diminished hydroxyproline accumulation due to HCl instillation. Saline pretreatment at 72 h had no significant effect on the HCl injury and subsequent physiologic abnormalities. Our attempts to improve outcome with post-treatment instillation of KGF were unsuccessful. We conclude that KGF pretreatment reduces lung injury due to acid instillation and can prevent subsequent pulmonary fibrosis.<\/jats:p>","DOI":"10.1165\/ajrcmb.15.4.8879176","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T22:28:10Z","timestamp":1365028090000},"page":"433-442","source":"Crossref","is-referenced-by-count":148,"title":["Keratinocyte Growth Factor Reduces Lung Damage Due to Acid Instillation in Rats"],"prefix":"10.1093","volume":"15","author":[{"given":"T","family":"Yano","sequence":"first","affiliation":[{"name":"Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R R","family":"Deterding","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W S","family":"Simonet","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Shannon","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R J","family":"Mason","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1996,10,1]]},"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/15\/4\/433\/67385239\/ajrcmb_15_4_433.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/15\/4\/433\/67385239\/ajrcmb_15_4_433.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:21:28Z","timestamp":1773800488000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/15\/4\/433\/8526872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1996,10,1]]},"published-print":{"date-parts":[[1996,10,1]]}},"URL":"https:\/\/doi.org\/10.1165\/ajrcmb.15.4.8879176","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1996,10]]},"published":{"date-parts":[[1996,10,1]]}}}