{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:47:45Z","timestamp":1772930865872,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1997,8,1]],"date-time":"1997-08-01T00:00:00Z","timestamp":870393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Exudative pleural effusions are characterized by a high protein content and frequently progress to loculation and fibrosis. To test the hypothesis that tissue factor (TF) plays an integral role in this process, we investigated the expression of TF by human mesothelial cells (HMC) both in vivo and in vitro, and measured the effect of serum on HMC expression of TF in vitro. In vivo TF expression was not detected in HMC of normal pleura, but was detected in HMC of pleura overlying inflamed lung. In vitro, quiescent HMC demonstrated negligible levels of TF expression; however, upon serum stimulation there was a marked induction in both TF protein level and activity, peaking at 8\u20139 h. In contrast, treating quiescent HMC with plasma resulted in a further small, but significant, decrease in TF expression. This serum-induced rise in TF was also reflected in TF mRNA levels and did not require de novo protein synthesis. These results suggest that induction of HMC TF expression may be important in triggering both the intrapleural activation of prothrombin and the deposition of fibrin characteristic of inflammatory effusions.<\/jats:p>","DOI":"10.1165\/ajrcmb.17.2.2438","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T22:21:53Z","timestamp":1365027713000},"page":"164-172","source":"Crossref","is-referenced-by-count":21,"title":["Tissue Factor Expression in Mesothelial Cells: Induction Both\n                    <i>In Vivo<\/i>\n                    and\n                    <i>In Vitro<\/i>"],"prefix":"10.1093","volume":"17","author":[{"given":"Kurt D.","family":"Bottles","sequence":"first","affiliation":[{"name":"Department of Medicine, Pulmonary and Critical Care Medicine, and Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City; and Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoltan","family":"Laszik","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pulmonary and Critical Care Medicine, and Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City; and Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"Morrissey","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pulmonary and Critical Care Medicine, and Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City; and Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary T.","family":"Kinasewitz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pulmonary and Critical Care Medicine, and Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City; and Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1997,8,1]]},"reference":[{"key":"2026030700215623800_B1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00000441-199501000-00008","article-title":"Review: Pathophysiology of the pleural space.","volume":"309","author":"Boggs","year":"1995","journal-title":"Am. 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Haemost."},{"key":"2026030700215623800_B9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1164\/ajrccm\/144.1.187","article-title":"Abnormalities of pathways of fibrin turnover in the human pleural space.","volume":"144","author":"Idell","year":"1991","journal-title":"Am. Rev. Respir. Dis."},{"key":"2026030700215623800_B10","first-page":"1087","article-title":"Selective cellular expression of tissue factor in human tissues implications for disorders of hemostasis and thrombosis.","volume":"134","author":"Drake","year":"1989","journal-title":"Am. J. Pathol."},{"key":"2026030700215623800_B11","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0049-3848(90)90148-6","article-title":"Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody.","volume":"59","author":"Fleck","year":"1990","journal-title":"Thromb. 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Res."},{"key":"2026030700215623800_B14","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jcp.1041390226","article-title":"Serum stimulation of quiescent human fibroblasts induces the synthesis of tissue factor mRNA followed by the appearance of tissue factor antigen and procoagulant activity.","volume":"139","author":"Bloem","year":"1989","journal-title":"J. Cell. Physiol."},{"key":"2026030700215623800_B15","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1042\/bj2730679","article-title":"Heterogeneous regulation of constitutive thrombomodulin or inducible tissue-factor activities on the surface of human saphenous-vein endothelial cells in culture following stimulation by interleukin-1, tumour necrosis factor, thrombin or phorbol ester.","volume":"273","author":"Archipoff","year":"1991","journal-title":"Biochem. 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Immunol."},{"key":"2026030700215623800_B22","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1096\/fasebj.2.11.3260881","article-title":"Stimulation of DNA synthesis in cultured primary human mesothelial cells by specific growth factors.","volume":"2","author":"Gabrielson","year":"1988","journal-title":"FASEB J."},{"key":"2026030700215623800_B23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0049-3848(88)90084-9","article-title":"Monoclonal antibody analysis of purified and cell-associated tissue factor.","volume":"52","author":"Morrissey","year":"1988","journal-title":"Thromb. Res."},{"key":"2026030700215623800_B24","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0049-3848(88)90197-1","article-title":"Resolution of monomeric and heterodimeric forms of tissue factor, the high-affinity cellular receptor for factor VII.","volume":"50","author":"Morrissey","year":"1988","journal-title":"Thromb. Res."},{"key":"2026030700215623800_B25","doi-asserted-by":"crossref","first-page":"14477","DOI":"10.1016\/S0021-9258(19)49737-8","article-title":"Deletion of the membrane anchoring region of tissue factor abolishes autoactivation of factor VII but not cofactor function.","volume":"267","author":"Neuenschwander","year":"1992","journal-title":"J. Biol. Chem."},{"key":"2026030700215623800_B26","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1182\/blood.V80.12.3127.3127","article-title":"An unusual antibody that blocks tissue factor\/factor VIIa function by inhibiting cleavage only of macromolecular substrates.","volume":"80","author":"Fiore","year":"1992","journal-title":"Blood"},{"key":"2026030700215623800_B27","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/00001721-199306000-00002","article-title":"Dexamethasone enhances agonist induction of tissue factor in monocytes but not in endothelial cells.","volume":"4","author":"Bottles","year":"1993","journal-title":"Blood Coagul. 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