{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:46:56Z","timestamp":1772930816985,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In lung transplantation, a substantial number of donor leukocytes are transferred from the donor to the recipient by the graft. Using a rat model, it was analyzed in this study to what extent leukocytes leave the lung, to which phenotype they belong, and to which organs they migrate. The model used was the orthotopic transplantation of the left lung of LEW.7B(RT7b) rats into LEW(RT7a) recipients. Lung allografts are not rejected in this strain combination, which differs only in the RT7 system, a genetic polymorphism of CD45. Using the RT7b marker (monoclonal antibody His41), the distribution of donor leukocytes passively transferred with the graft was studied by immunohistology 2 wk after transplantation. At this time, 2.9 \u00b1 0.1% (n = 6) of the peripheral blood leukocytes in the recipients were derived from the donor lung. The donor cell population detected in the blood consisted of T cells (59 \u00b1 4%), B cells (5.1 \u00b1 0.2%) and a surprisingly high fraction of natural killer (NK) cells (36 + 3%). No monocytes or granulocytes were found. In lymph nodes, spleen and thymus donor-derived T- and B-cells could be shown in typical T- and B-areas, respectively. Donor-derived leukocytes were found in the liver and the skin. In the tissue and the bronchoalveolar lavage (BAL) of the host lung, predominantly T cells were found. Furthermore, in the donor tissue and BAL more than 70% of T- and B-cells were host type, demonstrating that the donor lung had been repopulated to a great extent by host lymphocytes. This supports the relevance of BAL as a diagnostic tool in lung diseases. Thus, the lung is an immunologically important site, releasing lymphocytes which migrate to other organs and also attracting many lymphocytes from the circulation.<\/jats:p>","DOI":"10.1165\/ajrcmb.17.4.2599","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T22:24:26Z","timestamp":1365027866000},"page":"414-421","source":"Crossref","is-referenced-by-count":20,"title":["The Lung as a Source and a Target Organ for T- and B-lymphocytes"],"prefix":"10.1093","volume":"17","author":[{"given":"Thomas","family":"Tschernig","sequence":"first","affiliation":[{"name":"Departments of Functional and Applied Anatomy, Abdominal and Transplantation Surgery, and Cardiovascular Surgery, Medical School of Hannover, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Boeke","sequence":"additional","affiliation":[{"name":"Departments of Functional and Applied Anatomy, Abdominal and Transplantation Surgery, and Cardiovascular Surgery, Medical School of Hannover, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustav","family":"Steinhoff","sequence":"additional","affiliation":[{"name":"Departments of Functional and Applied Anatomy, Abdominal and Transplantation Surgery, and Cardiovascular Surgery, Medical School of Hannover, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Wonigeit","sequence":"additional","affiliation":[{"name":"Departments of Functional and Applied Anatomy, Abdominal and Transplantation Surgery, and Cardiovascular Surgery, Medical School of Hannover, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Pabst","sequence":"additional","affiliation":[{"name":"Departments of Functional and Applied Anatomy, Abdominal and Transplantation Surgery, and Cardiovascular Surgery, Medical School of Hannover, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Westermann","sequence":"additional","affiliation":[{"name":"Departments of Functional and Applied Anatomy, Abdominal and Transplantation Surgery, and Cardiovascular Surgery, Medical School of Hannover, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1997,10,1]]},"reference":[{"key":"2026030700203929700_B1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/0966-3274(95)80010-7","article-title":"Allogeneic lymphocyte chimerism after clinical lung transplantation.","volume":"3","author":"Richter","year":"1995","journal-title":"Transpl. Immunol."},{"key":"2026030700203929700_B2","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/hep.1840170629","article-title":"Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance.","volume":"17","author":"Starzl","year":"1993","journal-title":"Hepatology"},{"key":"2026030700203929700_B3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF00710098","article-title":"Lymphocytes in the lung: an often neglected cell: numbers, characterization and compartmentalization.","volume":"192","author":"Pabst","year":"1995","journal-title":"Anat. Embryol."},{"key":"2026030700203929700_B4"},{"key":"2026030700203929700_B5","first-page":"188","article-title":"Extraction of immune and inflammatory cells from human lung parenchyma: evaluation of an enzymatic digestion procedure.","volume":"66","author":"Holt","year":"1986","journal-title":"Clin. Exp. Immunol."},{"key":"2026030700203929700_B6"},{"key":"2026030700203929700_B7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00007890-198507000-00006","article-title":"Lung allograft rejection in the rat. I. Accelerated rejection caused by graft lymphocytes.","volume":"40","author":"Prop","year":"1985","journal-title":"Transplantation"},{"key":"2026030700203929700_B8","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/00007890-198508000-00003","article-title":"Lung allograft rejection in the rat. II. Specific immunological properties of lung grafts.","volume":"40","author":"Prop","year":"1985","journal-title":"Transplantation"},{"key":"2026030700203929700_B9","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1365-3083.1990.tb02821.x","article-title":"RT7- defined alloantigens in rats are part of the leucocyte common antigen family.","volume":"31","author":"Kampinga","year":"1990","journal-title":"Scand. J. Immunol."},{"key":"2026030700203929700_B10","first-page":"1631","article-title":"Characterization of the RT-Ly-1 and RT-Ly-2 alloantigenic systems by congenic rat strains.","volume":"11","author":"Wonigeit","year":"1979","journal-title":"Transplant. Proc."},{"key":"2026030700203929700_B11","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S0022-5223(19)38452-1","article-title":"Reimplantation response in isografted rat lung: analysis of causal factors.","volume":"87","author":"Prop","year":"1984","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"2026030700203929700_B12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/01902148709069597","article-title":"Comparative study of bronchoalveolar lavage fluid: effect of species, age and method of lavage.","volume":"13","author":"Henderson","year":"1987","journal-title":"Exp. Lung Res."},{"key":"2026030700203929700_B13","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.4049\/jimmunol.150.9.3843","article-title":"IFN-gamma influences the migration of thoracic duct B and T lymphocyte subsets in vivo.","volume":"150","author":"Westermann","year":"1993","journal-title":"J. Immunol."},{"key":"2026030700203929700_B14","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1084\/jem.169.4.1373","article-title":"Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokine activated killer cells.","volume":"169","author":"Chambers","year":"1989","journal-title":"J. Exp. 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