{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:12:00Z","timestamp":1791090720489,"version":"4.1.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nitric oxide radical (\u00b7NO) and peroxynitrite anion (ONOO\u2212) have been implicated in lung inflammation and may be important in pleural injury. The present study was undertaken to determine the effects of asbestos exposure and cytokine stimulation on \u00b7NO and ONOO\u2212 production by rat pleural mesothelial cells. Accordingly, rat parietal pleural mesothelial cells were cultured for 2 to 72 h with or without 50 ng\/ml of recombinant interleukin-1\u03b2 (IL-1\u03b2) in the presence (1.05 to 8.4 \u03bcg\/cm2) or absence of crocidolite or chrysotile asbestos fibers. The effects of asbestos were compared with those of carbonyl iron, a nonfibrogenic particulate. Mesothelial cell messenger RNA (mRNA) expression of the inducible form of \u00b7NO synthase (iNOS), assessed with the reverse transcription\u2013polymerase chain reaction (RT\u2013PCR), increased progressively from 2 to 12 h in IL-1\u03b2-containing cultures. Nitrite (NO2\u2212), the stable oxidation product of \u00b7NO in mesothelial cell conditioned medium, was assayed through the Griess reaction. Both types of asbestos fibers (chrysotile &amp;gt; crocidolite) upregulated the formation of NO2\u2212 in mesothelial cells costimulated with IL-1\u03b2 in a concentration-dependent and time-dependent fashion. In contrast, carbonyl iron did not upregulate NO2\u2212 formation in IL-1\u03b2-stimulated cells. Both types of asbestos fibers also induced iNOS protein expression and the formation of nitrotyrosine in mesothelial cells and greatly induced the formation of nitrate (NO3\u2212), a surrogate marker of ONOO\u2212 formation, in IL-1\u03b2-stimulated cells. However, the effects of chrysotile were notably greater than those of crocidolite. These findings may have significance for the induction of pleural injury by asbestos fibers.<\/jats:p>","DOI":"10.1165\/ajrcmb.19.2.3111","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T22:18:32Z","timestamp":1365027512000},"page":"226-236","source":"Crossref","is-referenced-by-count":74,"title":["Asbestos Fibers and Interleukin-1 Upregulate the Formation of Reactive Nitrogen Species in Rat Pleural Mesothelial Cells"],"prefix":"10.1093","volume":"19","author":[{"given":"Nonghoon","family":"Choe","sequence":"first","affiliation":[{"name":"Department of Pathology, Uniformed Services University of the Health Sciences, F. Edward H\u00e9bert School of Medicine, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pathology, Uniformed Services University of the Health Sciences, F. Edward H\u00e9bert School of Medicine, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott","family":"Kagan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Uniformed Services University of the Health Sciences, F. 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