{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:06:46Z","timestamp":1790896006006,"version":"4.1.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inactivation of the integrin \u03b26 subunit gene in mice resulted in an unexpected phenotype\u2014functionally significant inflammation of the skin and lungs. These findings suggested a role for ligation of the \u03b1v\u03b26 integrin on epithelial cells in downregulating epithelial inflammation. However, the results of gene inactivation could have been due to inactivation of adjacent genes and provided no information about the role of this integrin in specific populations of epithelial cells. In the current study, we used transgenic mice constitutively expressing the human \u03b26 subunit in alveolar type II cells and bronchiolar epithelial cells to examine directly the significance of \u03b1v\u03b26 in these cells. Expression of this transgene largely inhibited the increases in airspace lymphocytes and macrophages and the lymphocyte and macrophage activation caused by inactivation of the \u03b26 subunit gene, and reduced the peribronchial and perivascular accumulations of lymphocytes. In the genetically mixed mice used for this study, we identified airway eosinophilia as an additional effect of \u03b26 inactivation. This effect was also partially inhibited by limited expression of the human transgene. These results definitively identify a role for distal lung epithelial \u03b1v\u03b26 in downregulating pulmonary inflammation and suggest that interventions augmenting \u03b26 expression or function in these cells could influence the course of inflammatory lung diseases.<\/jats:p>","DOI":"10.1165\/ajrcmb.19.4.3293","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T22:21:45Z","timestamp":1365027705000},"page":"636-642","source":"Crossref","is-referenced-by-count":67,"title":["Expression of the Human Integrin \u03b2 6 Subunit in Alveolar Type II Cells and Bronchiolar Epithelial Cells Reverses Lung Inflammation in \u03b2 6 Knockout Mice"],"prefix":"10.1093","volume":"19","author":[{"given":"Xiaozhu","family":"Huang","sequence":"first","affiliation":[{"name":"Lung Biology Center, and the Department of Medicine, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Lung Biology Center, and the Department of Medicine, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Lung Biology Center, and the Department of Medicine, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Pytela","sequence":"additional","affiliation":[{"name":"Lung Biology Center, and the Department of Medicine, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Sheppard","sequence":"additional","affiliation":[{"name":"Lung Biology Center, and the Department of Medicine, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1998,10,1]]},"reference":[{"key":"2026030700162502800_B1","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1016\/S0021-9258(18)42622-1","article-title":"Characterization of the integrin \u03b1v\u03b26 as a fibronectin-binding protein.","volume":"267","author":"Busk","year":"1992","journal-title":"J. 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