{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:42:09Z","timestamp":1772930529968,"version":"3.50.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1999,3,1]],"date-time":"1999-03-01T00:00:00Z","timestamp":920246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A role for endothelial nitric oxide synthase (NOS3) in the susceptibility of individuals with \u03b11-antitrypsin (\u03b11AT) deficiency to destructive lung disease was evaluated. Six polymorphic sites were identified within the NOS3 gene (i.e., \u2212924A\/G, \u2212788C\/T, \u2212691C\/T, 774C\/T, 894G\/T, and 1998C\/G). The genotype distribution was determined in 339 patients and 94 control individuals. Frequency of the 774T allele in severely affected individuals was 0.417 versus 0.269 in control subjects (P = 0.018), whereas the 894T allele frequency was 0.427 versus 0.280 in control subjects (P = 0.024). Patients with less severe lung disease had the 774T and 894T allele frequencies of 0.289 and 0.344, respectively, similar to frequencies in a control group (P &amp;gt; 0.3). No direct correlation between pulmonary function and five other NOS3 polymorphisms was observed. Thus, functional allelic variants that are in linkage disequilibrium with the 774C\/T and 894G\/T may be present in the specified genomic area. These data are consistent with a modulatory role for NOS3 in destructive lung disease associated with \u03b11AT deficiency.<\/jats:p>","DOI":"10.1165\/ajrcmb.20.3.3144","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T21:53:09Z","timestamp":1365025989000},"page":"441-447","source":"Crossref","is-referenced-by-count":57,"title":["Endothelial Nitric Oxide Synthase as a Potential Susceptibility Gene in the Pathogenesis of Emphysema in \u03b1 1-Antitrypsin Deficiency"],"prefix":"10.1093","volume":"20","author":[{"given":"Alexey","family":"Novoradovsky","sequence":"first","affiliation":[{"name":"Pulmonary\u2013Critical Care Medicine Branch, and Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark L.","family":"Brantly","sequence":"additional","affiliation":[{"name":"Pulmonary\u2013Critical Care Medicine Branch, and Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myron A.","family":"Waclawiw","sequence":"additional","affiliation":[{"name":"Pulmonary\u2013Critical Care Medicine Branch, and Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prerna P.","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Pulmonary\u2013Critical Care Medicine Branch, and Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideshi","family":"Ihara","sequence":"additional","affiliation":[{"name":"Pulmonary\u2013Critical Care Medicine Branch, and Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Qi","sequence":"additional","affiliation":[{"name":"Pulmonary\u2013Critical Care Medicine Branch, and Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Tony Eissa","sequence":"additional","affiliation":[{"name":"Pulmonary\u2013Critical Care Medicine Branch, and Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline M.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Pulmonary\u2013Critical Care Medicine Branch, and Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kateri M.","family":"Gabriele","sequence":"additional","affiliation":[{"name":"Pulmonary\u2013Critical Care Medicine Branch, and Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E.","family":"Ehrmantraut","sequence":"additional","affiliation":[{"name":"Pulmonary\u2013Critical Care Medicine Branch, and Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Rogliani","sequence":"additional","affiliation":[{"name":"Pulmonary\u2013Critical Care Medicine Branch, and Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Moss","sequence":"additional","affiliation":[{"name":"Pulmonary\u2013Critical Care Medicine Branch, and Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,3,1]]},"reference":[{"key":"2026030700134383800_B1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"NO: physiology, pathophysiology and pharmacology.","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. 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