{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:42:12Z","timestamp":1790422932301,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We examined the roles of B7-1 (CD80) and B7-2 (CD86) in a model of allergic pulmonary inflammation and airway hyperresponsiveness (AHR) by using mice with germline deletions of the B7-1 and\/or B7-2 molecules. Multiple parameters of the allergic response were affected to varying degrees by the absence of B7-1 and\/or B7-2. Mice lacking both B7-1 and B7-2 had no elevation of serum immunoglobulin E, lack of airway eosinophilia, and no AHR. These same disease parameters were also reduced in mice lacking either B7-1 or B7-2. Lack of B7-1 and\/or B7-2 resulted in an increase in T-helper 1 cytokine production. Our observations suggest that whereas B7-2 is quantitatively more significant in the induction of this response, B7-1 and B7-2 may have complementary roles in mediating the development of allergic pulmonary inflammation.<\/jats:p>","DOI":"10.1165\/ajrcmb.22.3.3747","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T21:39:08Z","timestamp":1365025148000},"page":"265-271","source":"Crossref","is-referenced-by-count":44,"title":["B7-1 (CD80) and B7-2 (CD86) Have Complementary Roles in Mediating Allergic Pulmonary Inflammation and Airway Hyperresponsiveness"],"prefix":"10.1093","volume":"22","author":[{"given":"David A.","family":"Mark","sequence":"first","affiliation":[{"name":"Pulmonary Division, Renal Division, and Department of Pathology, Brigham and Women's Hospital; and Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn E.","family":"Donovan","sequence":"additional","affiliation":[{"name":"Pulmonary Division, Renal Division, and Department of Pathology, Brigham and Women's Hospital; and Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George T.","family":"De Sanctis","sequence":"additional","affiliation":[{"name":"Pulmonary Division, Renal Division, and Department of Pathology, Brigham and Women's Hospital; and Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Zhen","family":"He","sequence":"additional","affiliation":[{"name":"Pulmonary Division, Renal Division, and Department of Pathology, Brigham and Women's Hospital; and Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Cernadas","sequence":"additional","affiliation":[{"name":"Pulmonary Division, Renal Division, and Department of Pathology, Brigham and Women's Hospital; and Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lester","family":"Kobzik","sequence":"additional","affiliation":[{"name":"Pulmonary Division, Renal Division, and Department of Pathology, Brigham and Women's Hospital; and Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Pulmonary Division, Renal Division, and Department of Pathology, Brigham and Women's Hospital; and Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene","family":"Sharpe","sequence":"additional","affiliation":[{"name":"Pulmonary Division, Renal Division, and Department of Pathology, Brigham and Women's Hospital; and Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia W.","family":"Finn","sequence":"additional","affiliation":[{"name":"Pulmonary Division, Renal Division, and Department of Pathology, Brigham and Women's Hospital; and Departments of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,3,1]]},"reference":[{"key":"2026030700082991300_B1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1398-9995.1995.tb02730.x","article-title":"The airway inflammatory response in allergic asthma and its relationship to clinical disease.","volume":"50","author":"Howarth","year":"1995","journal-title":"Allergy"},{"key":"2026030700082991300_B2","first-page":"L476","article-title":"T cell activation in a murine model of asthma.","volume":"271","author":"Krinzman","year":"1996","journal-title":"Am. 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