{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:09:26Z","timestamp":1791112166929,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Spontaneous contractions of the fetal airways are a well recognized but poorly characterized phenomenon. In the present study spontaneous narrowing of the airways was analyzed in freshly isolated lungs from early to late gestation in fetal pigs and rabbits and in cultured fetal mouse lungs. Propagating waves of contraction traveling proximal to distal were observed in fresh lungs throughout gestation which displaced the lung liquid along the lumen. In the pseudoglandular and canalicular stages (fetal pigs) the frequency ranged from 2.3 to 3.3 contractions\/min with a 39 to 46% maximum reduction of lumen diameter. In the saccular stage (rabbit) the frequency was 10 to 12\/min with a narrowing of \u223c 30%. In the organ cultures the waves of narrowing started at the trachea in whole lungs, or at the main bronchus in lobes (5.2 \u00b1 1.5 contractions\/min, 22 \u00b1 8% reduction of lumen diameter), and as they proceeded distally along the epithelial tubes the luminal liquid was shifted toward the terminal tubules, which expanded the endbuds. As the tubules relaxed the flow of liquid was reversed. Thus the behavior of airway smooth muscle in the fetal lung is phasic in type (like gastrointestinal muscle) in contrast to that in postnatal lung, where it is tonic. An intraluminal positive pressure of 2.33 \u00b1 0.77 cm H2O was recorded in rabbit fetal trachea. It is proposed that the active tone of the smooth muscle maintains the positive intraluminal pressure and acts as a stimulus to lung growth via the force exerted across the airway wall and adjacent parenchyma. The expansion of the compliant endbuds by the fluid shifts at the airway tip may promote their growth into the surrounding mesenchyme.<\/jats:p>","DOI":"10.1165\/ajrcmb.23.1.3926","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T21:38:04Z","timestamp":1365025084000},"page":"11-18","source":"Crossref","is-referenced-by-count":142,"title":["Spontaneous Peristaltic Airway Contractions Propel Lung Liquid through the Bronchial Tree of Intact and Fetal Lung Explants"],"prefix":"10.1093","volume":"23","author":[{"given":"Johannes C.","family":"Schittny","sequence":"first","affiliation":[{"name":"Institute of Anatomy, University of Bern, Bern, Switzerland; Istituto di Fisiologia Umana, Facolt\u00e0 di Medicina e Chirurgia, Universit\u00e0 degli Studi, Milan, Italy; and Department of Physiology, University of Western Australia, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Miserocchi","sequence":"additional","affiliation":[{"name":"Institute of Anatomy, University of Bern, Bern, Switzerland; Istituto di Fisiologia Umana, Facolt\u00e0 di Medicina e Chirurgia, Universit\u00e0 degli Studi, Milan, Italy; and Department of Physiology, University of Western Australia, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm P.","family":"Sparrow","sequence":"additional","affiliation":[{"name":"Institute of Anatomy, University of Bern, Bern, Switzerland; Istituto di Fisiologia Umana, Facolt\u00e0 di Medicina e Chirurgia, Universit\u00e0 degli Studi, Milan, Italy; and Department of Physiology, University of Western Australia, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,7,1]]},"reference":[{"key":"2026030700040573600_B1"},{"key":"2026030700040573600_B2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.1975.sp010796","article-title":"Excitation and contraction in bovine tracheal smooth muscle.","volume":"244","author":"Kirkpatrick","year":"1975","journal-title":"J. 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