{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:33:35Z","timestamp":1772930015186,"version":"3.50.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this study we examined the effect of oral antigen (Ag) administration on the development of experimental asthma in different mouse strains. We selected BALB \/ c, BP2, CBA \/ Ca interleukin (IL)-5 transgenic, and BALB \/ c T-cell receptor-\u03b4 \u2013deficient mouse strains because they exhibit different aspects of the asthma syndrome. Mice exposed to 1% ovalbumin (OVA), dissolved in the drinking water for 5 consecutive days, became unresponsive to subsequent immunogenic OVA challenges. This regimen of OVA administration induced Ag-specific unresponsiveness in all mouse strains tested, including \u03b3\u03b4-deficient mice that are said to be resistant to tolerance induction. The Ag-specific unresponsiveness was characterized by reduced (almost absent) airway eosinophilic inflammation, airway hyperreactivity, and mucus production; also by low levels of T helper (Th) 2-type cytokines in bronchoalveolar lavage fluid, and decreased immunoglobulin (Ig) G1 and IgE OVA-specific antibody production. The unresponsive state was not associated with increased levels of the suppressive cytokines IL-10 and transforming growth factor (TGF)-\u03b2 or with immune deviation toward the Th1 pathway due to increased levels of interferon-\u03b3 and IL-12. Moreover, treatment with anti\u2013TGF-\u03b2 antibodies did not abrogate oral tolerance. Oral Ag administration was quite effective in suppressing the development of key features of asthma when initiated after primary immunization (Day 0) or after booster (Day 7), but not after challenge (Day 14) when it increased allergic responses. Collectively, our findings show for the first time the beneficial and detrimental effects of oral Ag administration on the development of experimental asthma.<\/jats:p>","DOI":"10.1165\/ajrcmb.24.5.4320","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T21:26:44Z","timestamp":1365024404000},"page":"518-526","source":"Crossref","is-referenced-by-count":102,"title":["Suppression of Asthma-like Responses in Different Mouse Strains by Oral Tolerance"],"prefix":"10.1093","volume":"24","author":[{"given":"Momtchilo","family":"Russo","sequence":"first","affiliation":[{"name":"Departamento de Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil; Institut Pasteur Unit\u00e9 de Pharmacologie Cellulaire, Unit\u00e9 Associ\u00e9e Institut Pasteur-INSERM U485; and Laboratoire d'Immuno-differenciation, Universit\u00e9 Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Anne","family":"Nahori","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil; Institut Pasteur Unit\u00e9 de Pharmacologie Cellulaire, Unit\u00e9 Associ\u00e9e Institut Pasteur-INSERM U485; and Laboratoire d'Immuno-differenciation, Universit\u00e9 Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Lefort","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil; Institut Pasteur Unit\u00e9 de Pharmacologie Cellulaire, Unit\u00e9 Associ\u00e9e Institut Pasteur-INSERM U485; and Laboratoire d'Immuno-differenciation, Universit\u00e9 Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliane","family":"Gomes","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil; Institut Pasteur Unit\u00e9 de Pharmacologie Cellulaire, Unit\u00e9 Associ\u00e9e Institut Pasteur-INSERM U485; and Laboratoire d'Immuno-differenciation, Universit\u00e9 Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"de Castro Keller","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil; Institut Pasteur Unit\u00e9 de Pharmacologie Cellulaire, Unit\u00e9 Associ\u00e9e Institut Pasteur-INSERM U485; and Laboratoire d'Immuno-differenciation, Universit\u00e9 Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dunia","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil; Institut Pasteur Unit\u00e9 de Pharmacologie Cellulaire, Unit\u00e9 Associ\u00e9e Institut Pasteur-INSERM U485; and Laboratoire d'Immuno-differenciation, Universit\u00e9 Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando Garcia","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil; Institut Pasteur Unit\u00e9 de Pharmacologie Cellulaire, Unit\u00e9 Associ\u00e9e Institut Pasteur-INSERM U485; and Laboratoire d'Immuno-differenciation, Universit\u00e9 Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahil","family":"Adriouch","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil; Institut Pasteur Unit\u00e9 de Pharmacologie Cellulaire, Unit\u00e9 Associ\u00e9e Institut Pasteur-INSERM U485; and Laboratoire d'Immuno-differenciation, Universit\u00e9 Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vallerie","family":"Gallois","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil; Institut Pasteur Unit\u00e9 de Pharmacologie Cellulaire, Unit\u00e9 Associ\u00e9e Institut Pasteur-INSERM U485; and Laboratoire d'Immuno-differenciation, Universit\u00e9 Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M. 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