{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:25:24Z","timestamp":1790166324316,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Interleukin (IL)-9 is a T-cell\u2013derived cytokine with pleiotropic activities on T helper 2 cells, B cells, and mast cells. IL-9 may therefore play an important role in the development of allergic pulmonary inflammatory diseases. In this study, an antimouse IL-9 (anti-mIL-9) antibody (Ab) was evaluated against pulmonary eosinophilia, histopathologic changes in lung tissues, serum immunoglobulin (Ig) E levels, and airway hyperresponsiveness (AHR) to methacholine in mice sensitized and challenged with ovalbumin (OVA). Additionally, steady-state levels of IL-4, IL-5, IL-13, and interferon- \u03b3 messenger RNA (mRNA) in the lungs were measured. The anti-mIL-9 Ab (200 \u03bc g\/mouse, intraperitoneally) was given as either four doses during the sensitization period or as a single dose before OVA challenge. Sensitized mice challenged with OVA displayed marked pulmonary eosinophilia, epithelial damage, and goblet cell hyperplasia. OVA challenge also increased mRNA levels of IL-4, IL-5, and IL-13 in the lungs. AHR was also increased twofold in sensitized, challenged mice. Treatment of sensitized, challenged mice with four doses of anti-mIL-9 Ab significantly reduced pulmonary eosinophilia, serum IgE levels, goblet cell hyperplasia, airway epithelial damage, and AHR, but had no effect on IL-4, IL-5, and IL-13 mRNA levels in the lungs. A single dose of the antibody was ineffective on all measures. These results indicate that an antibody to mIL-9 inhibits the development of allergic pulmonary inflammation and AHR in mice.<\/jats:p>","DOI":"10.1165\/ajrcmb.25.5.4533","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T21:33:22Z","timestamp":1365024802000},"page":"600-605","source":"Crossref","is-referenced-by-count":63,"title":["Effect of Anti-mIL-9 Antibody on the Development of Pulmonary Inflammation and Airway Hyperresponsiveness in Allergic Mice"],"prefix":"10.1093","volume":"25","author":[{"given":"Ted T.","family":"Kung","sequence":"first","affiliation":[{"name":"Department of Allergy, Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Allergy, Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette","family":"Crawley","sequence":"additional","affiliation":[{"name":"Department of Allergy, Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles G.","family":"Garlisi","sequence":"additional","affiliation":[{"name":"Department of Allergy, Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Devito","sequence":"additional","affiliation":[{"name":"Department of Allergy, Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Minnicozzi","sequence":"additional","affiliation":[{"name":"Department of Allergy, Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Egan","sequence":"additional","affiliation":[{"name":"Department of Allergy, Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Kreutner","sequence":"additional","affiliation":[{"name":"Department of Allergy, Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Department of Allergy, Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,11,1]]},"reference":[{"key":"2026030700002063400_B1","doi-asserted-by":"crossref","first-page":"13175","DOI":"10.1073\/pnas.94.24.13175","article-title":"Interleukin 9: a candidate gene for asthma.","volume":"94","author":"Nicolaides","year":"1997","journal-title":"Proc. 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