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Lymphocytes from silica-exposed lymph nodes showed reduced mitogenic responses to T cell receptor (TCR) stimulation, and markedly increased activation-induced cell death, compared with control lymphocytes from saline-exposed lymph nodes. CD4+ T cell death was mediated by Fas ligand, because CD4+ T cells from Fas ligand\u2013deficient gld mice did not undergo activation-induced apoptosis. Silica deposition also resulted in increased apoptosis associated with inflammatory infiltrates in lung parenchyma. In vivo treatment with caspase inhibitors reduced neutrophil accumulation, and alleviated inflammation in the lungs of silica-treated mice. These results suggest that silica-induced apoptosis plays an inflammatory role in the lung parenchyma, and creates immunologic abnormalities in regional lymph nodes, with pathogenic implications for the host.<\/jats:p>","DOI":"10.1165\/ajrcmb.27.1.4717","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T21:19:47Z","timestamp":1365023987000},"page":"78-84","source":"Crossref","is-referenced-by-count":60,"title":["Apoptosis Underlies Immunopathogenic Mechanisms in Acute Silicosis"],"prefix":"10.1093","volume":"27","author":[{"given":"Valeria M.","family":"Borges","sequence":"first","affiliation":[{"name":"Instituto de Biof\u013asica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; and Immunology Department, Holland Laboratory, American Red Cross, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela F.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u013asica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; and Immunology Department, Holland Laboratory, American Red Cross, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haroldo","family":"Falca\u00f5","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u013asica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; and Immunology Department, Holland Laboratory, American Red Cross, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Henrique","family":"Leite-Ju\u0144ior","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u013asica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; and Immunology Department, Holland Laboratory, American Red Cross, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia R. M.","family":"Rocco","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u013asica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; and Immunology Department, Holland Laboratory, American Red Cross, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy F.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u013asica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; and Immunology Department, Holland Laboratory, American Red Cross, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Linden","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u013asica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; and Immunology Department, Holland Laboratory, American Red Cross, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter A.","family":"Zin","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u013asica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; and Immunology Department, Holland Laboratory, American Red Cross, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A.","family":"DosReis","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u013asica Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; and Immunology Department, Holland Laboratory, American Red Cross, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,7,1]]},"reference":[{"key":"2026030623545248700_B1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0952-7915(99)80009-0","article-title":"Phagocytosis and development: back to the future.","volume":"11","author":"Franc","year":"1999","journal-title":"Curr. 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