{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:29:15Z","timestamp":1772929755017,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aim of this study was to investigate whether the effect of bacillus Calmette-Gu\u00e9rin (BCG) immunization on ovalbumin-induced allergic inflammation in a rat model depends on the genetic predisposition to react with a T helper cell (Th) 2-type cytokine response. This study was performed in an inbred Th2-predisposed \u201casthma prone\u201d rat strain (brown Norway [BN]) and in an outbred nonpredisposed strain (Sprague Dawley [SD]), to differentiate between genetic and environmental factors. BCG decreased numbers of lung eosinophils and macrophages in the SD rat. This effect was not seen in the BN rat. In the BN rat, but not in the SD rat, BCG downregulated levels of total serum IgE. No significant differences were found with respect to frequencies of IFN\u03b3\u2013 or interleukin-4\u2013producing cells in the lung in both rat strains. These results indicate that the degree and pathway of immunomodulatory effect of BCG in two genetically different rat strains is dependent on the genetic predisposition to develop a Th2-type response. Therefore, differences in genotype in relation to environment may result in difference in involvement of contributing pathogenic factors and thus different responsiveness to therapeutic strategies.<\/jats:p>","DOI":"10.1165\/ajrcmb.27.2.4735","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T21:09:02Z","timestamp":1365023342000},"page":"244-249","source":"Crossref","is-referenced-by-count":14,"title":["The Effect of Bacillus Calmette-Gu\u00e9rin Immunization Depends on the Genetic Predisposition to Th2-Type Responsiveness"],"prefix":"10.1093","volume":"27","author":[{"given":"Machteld N.","family":"Hylkema","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen; and Department of Pediatrics, Wilhelmina Children's Hospital, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim","family":"Timens","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen; and Department of Pediatrics, Wilhelmina Children's Hospital, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjan","family":"Luinge","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen; and Department of Pediatrics, Wilhelmina Children's Hospital, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nienke","family":"van der Werf","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen; and Department of Pediatrics, Wilhelmina Children's Hospital, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten O.","family":"Hoekstra","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen; and Department of Pediatrics, Wilhelmina Children's Hospital, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,8,1]]},"reference":[{"key":"2026030623564098100_BIB1","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1164\/ajrccm\/146.4.888","volume":"146","year":"1992","journal-title":"Am. 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