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In the present study, we demonstrate that human (h) MCs in nasal polyps and cultured cord blood\u2013derived hMCs express CCR3 not only on their surfaces but also in their secretory granules. Activation of hMCs mediated by the high-affinity Fc receptor for immunoglobulin (Ig)E (Fc\u03b5RI) increased the surface presentation of CCR3 within 1 h, with a parallel decrease in intracellular CCR3 as determined by flow cytometry on saponin-permeabilized hMCs. Recombinant eotaxin-1 alone did not induce histamine release or cytokine generation, and did not significantly augment IgE-dependent histamine release by interleukin (IL)-4\u2013primed hMCs. Nevertheless, stimulation of hMCs with eotaxin-1 2 h after Fc\u03b5RI cross-linkage (concomitantly with maximal surface CCR3 expression) increased Fc\u03b5RI-dependent IL-13 generation by hMCs, compared with their replicates stimulated simultaneously with both agonists. Thus, hMCs may store CCR3 and rapidly mobilize it to their surface with IgE-dependent activation, providing a novel potential mechanism for enhanced hMC effector function, including IL-13 production.<\/jats:p>","DOI":"10.1165\/rcmb.2002-0155oc","type":"journal-article","created":{"date-parts":[[2003,3,24]],"date-time":"2003-03-24T17:06:02Z","timestamp":1048525562000},"page":"420-427","source":"Crossref","is-referenced-by-count":41,"title":["CC Chemokine Receptor 3 Mobilizes to the Surface of Human Mast Cells and Potentiates Immunoglobulin E\u2013Dependent Generation of Interleukin 13"],"prefix":"10.1093","volume":"28","author":[{"given":"Kursteen S.","family":"Price","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital; and Departments of Medicine, Pediatrics, and Pathology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Friend","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital; and Departments of Medicine, Pediatrics, and Pathology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Mellor","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital; and Departments of Medicine, Pediatrics, and Pathology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidia","family":"De Jesus","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital; and Departments of Medicine, Pediatrics, and Pathology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald F. 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