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The current study was undertaken to elucidate the host-dependent pulmonary and immunologic response to M. pneumoniae respiratory infection by studying mice with different immunogenetic backgrounds (BALB\/c mice versus C57BL\/6 mice). After M. pneumoniae infection, only BALB\/c mice developed significant airway obstruction (AO) compared with controls. M. pneumoniae\u2013infected BALB\/c mice manifested significantly elevated airway hyperresponsiveness (AHR) compared with C57BL\/6 mice 4 and 7 d after inoculation as well as BALB\/c control mice. Compared with C57BL\/6 mice, BALB\/c mice developed worse pulmonary inflammation, including greater peribronchial infiltrates. Infected BALB\/c mice had significantly higher concentrations of tumor necrosis factor-\u03b1, interferon-\u03b3, interleukin (IL)-1\u03b2, IL-6, IL-12, KC (functional IL-8), and macrophage inflammatory protein 1\u03b1 in the bronchoalveolar lavage fluid compared with infected C57BL\/6 mice. No differences in IL-2, IL-4, IL-5, IL-10, and granulocyte\/macrophage colony-stimulating factor concentrations were found. The mice in this study exhibited host-dependent infection-related AO and AHR associated with chemokine and T-helper type (Th)1 pulmonary host response and not Th2 response after M. pneumoniae infection.<\/jats:p>","DOI":"10.1165\/rcmb.2004-0197oc","type":"journal-article","created":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T20:14:14Z","timestamp":1104437654000},"page":"201-210","source":"Crossref","is-referenced-by-count":58,"title":["<i>Mycoplasma pneumoniae<\/i>\n                    Induces Host-Dependent Pulmonary Inflammation and Airway Obstruction in Mice"],"prefix":"10.1093","volume":"32","author":[{"given":"Monica","family":"Fonseca-Aten","sequence":"first","affiliation":[{"name":"Departments of Pediatrics, Internal Medicine, and Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Internal Medicine, and Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asunci\u00f3n","family":"Mej\u00edas","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Internal Medicine, and Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Ch\u00e1vez-Bueno","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Internal Medicine, and Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Katz","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Internal Medicine, and Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Internal Medicine, and Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"George H.","family":"McCracken","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Internal Medicine, and Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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