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Here we report a marked decrease in interferon (IFN)-\u03b3 expression in both sporadic and TSC-associated AML and LAM. A marked increase in Stat1 expression and phosphorylation at Ser 727, and in phospho-Tyr705-Stat3 levels, was also seen in both AML and LAM tissues. Our results demonstrate that the IFN-\u03b3-Jak-Stat pathway is perturbed in TSC-related and sporadic LAM and AML, and suggest that IFN-\u03b3 has potential therapeutic benefit for treatment of those lesions.<\/jats:p>","DOI":"10.1165\/rcmb.2005-0152rc","type":"journal-article","created":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T20:17:07Z","timestamp":1120249027000},"page":"227-230","source":"Crossref","is-referenced-by-count":30,"title":["Interferon-\u03b3-Jak-Stat Signaling in Pulmonary Lymphangioleiomyomatosis and Renal Angiomyolipoma"],"prefix":"10.1093","volume":"33","author":[{"given":"Nisreen","family":"El-Hashemite","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital, Hematology Division, Department of Medicine, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Kwiatkowski","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Hematology 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