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Optimal T-cell activation requires not only presentation of antigen with the major histocompatibility complex, but also concurrent signaling through costimulatory molecules. The costimulatory molecule SLAM (Signaling Lymphocytic Activation Molecule, CD150) is a glycoprotein expressed on activated lymphocytes and antigen-presenting cells. Disruption of the SLAM gene demonstrated that SLAM-induced signal transduction pathways regulate cytokine production by T helper (Th)2 cells and macrophages. Here we tested the postulate that the costimulatory molecule SLAM may be critical for allergic inflammation in a murine model. SLAM-deficient mice did not manifest allergen-induced bronchoalveolar lavage eosinophilia, increased serum IgE, or heightened airway responses compared with wild-type mice. Allergen-induced Th2 cytokines and Th1 cytokines were decreased in SLAM-deficient mice. These data support the concept that SLAM plays a crucial role in allergic responses.<\/jats:p>","DOI":"10.1165\/rcmb.2005-0294oc","type":"journal-article","created":{"date-parts":[[2006,3,9]],"date-time":"2006-03-09T21:04:58Z","timestamp":1141938298000},"page":"206-210","source":"Crossref","is-referenced-by-count":10,"title":["The Costimulatory Molecule SLAM Is Critical for Pulmonary Allergic Responses"],"prefix":"10.1093","volume":"35","author":[{"given":"Ninghai","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Immunology, Beth Israel Deaconess Medical Center; and Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Campo","sequence":"additional","affiliation":[{"name":"Division of Immunology, Beth Israel Deaconess Medical Center; and Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical 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