{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:28:26Z","timestamp":1791156506972,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neuroimmune interactions play a critical role in the pathogenesis of asthma. Symptoms like wheezing and cough have been attributed to neural dysregulation, whereas sensitization and the induction of allergic inflammation have been linked with the activity of dendritic cells. Neuropeptides were previously shown to control dendritic cell function in vitro, suggesting interactions between dendritic cells and sensory nerves. Here we characterized the anatomical basis of the interactions between dendritic cells and nerves in the airways of mice and monitored the changes during allergic inflammation. Airway microdissection, whole-mount immunohistology, and confocal microscopy were used for the three-dimensional quantitative mapping of airway nerves and dendritic cells along the main axial pathway of nonsensitized versus ovalbumin-sensitized and -challenged CD11c-enhanced yellow fluorescent protein (CD11c-EYFP) transgenic mice. CD11c-EYFP\u2013positive airway mucosal dendritic cells were contacted by calcitonin gene-related peptide\u2013immunoreactive sensory fibers and their co-localization increased in allergic inflammation. Moreover, protein gene product 9.5\u2013positive neuroepithelial bodies and airway ganglia were associated with dendritic cells. In human airways, human leukocyte antigen DR\u2013positive mucosal dendritic cells were found in the close proximity of sensory nerves and neuroepithelial cells. These results provide morphologic evidence of the interactions between dendritic cells and the neural network of the airways at multiple anatomical sites.<\/jats:p>","DOI":"10.1165\/rcmb.2007-0087oc","type":"journal-article","created":{"date-parts":[[2007,6,28]],"date-time":"2007-06-28T21:27:47Z","timestamp":1183066067000},"page":"553-561","source":"Crossref","is-referenced-by-count":70,"title":["Spatial Interactions between Dendritic Cells and Sensory Nerves in Allergic Airway Inflammation"],"prefix":"10.1093","volume":"37","author":[{"given":"Tibor Z.","family":"Veres","sequence":"first","affiliation":[{"name":"Department of Immunology, Allergology and Immunotoxicology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Rochlitzer","sequence":"additional","affiliation":[{"name":"Department of Immunology, Allergology and Immunotoxicology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Shevchenko","sequence":"additional","affiliation":[{"name":"Department of Immunology, Allergology and Immunotoxicology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany"},{"name":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Immunology, Allergology and Immunotoxicology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Prenzler","sequence":"additional","affiliation":[{"name":"Department of Immunology, Allergology and Immunotoxicology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Nassenstein","sequence":"additional","affiliation":[{"name":"Department of Immunology, Allergology and Immunotoxicology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Fischer","sequence":"additional","affiliation":[{"name":"Clinical Research Unit of Allergy, Charit\u00e9 Campus-Virchow, Charit\u00e9 School of Medicine, Humboldt University, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Welker","sequence":"additional","affiliation":[{"name":"Cytological Laboratory, Hospital Grosshansdorf, Centre for Pneumology and Thoracic Surgery, Grosshansdorf, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Holz","sequence":"additional","affiliation":[{"name":"Cytological Laboratory, Hospital 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