{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:01:42Z","timestamp":1782961302280,"version":"3.54.5"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Increased activity of matrix metalloproteinase (MMP)-9 is associated with the development of bronchopulmonary dysplasia (BPD) in newborn infants, but the role of MMP-9 in the pathophysiology of BPD is unclear. We have shown that perinatal expression of interleukin-1\u03b2 (IL-1\u03b2) in the lung is sufficient to cause a BPD-like illness in infant mice. To study the hypothesis that MMP-9 is an important downstream mediator in IL-1\u03b2\u2013induced lung injury in the newborn, we compared the effects of IL-1\u03b2 on fetal and postnatal lung inflammation and development in transgenic mice with regulatable pulmonary overexpression of human mature IL-1\u03b2 with wild-type (IL-1\u03b2\/MMP-9+\/+) or null (IL-1\u03b2\/MMP-9\u2212\/\u2212) MMP-9 loci. IL-1\u03b2 increased the expression of MMP-9 mRNA and amount of MMP-9 protein in the lungs of MMP-9+\/+ mice. IL-1\u03b2\/MMP-9\u2212\/\u2212 mice had fewer neutrophils but more macrophages in the lungs than did IL-1\u03b2\/MMP-9+\/+ mice. MMP-9 deficiency increased pulmonary cell death and macrophage clearance of dying cells in IL-1\u03b2\u2013expressing mice. IL-1\u03b2\/MMP-9\u2212\/\u2212 mice had more severe alveolar hypoplasia than IL-1\u03b2\/MMP-9+\/+ mice, implying that IL-1\u03b2\u2013induced lung disease was worsened in the absence of MMP-9. These results suggest that MMP-9 activity in the inflamed neonatal lung protects the lung against injury.<\/jats:p>","DOI":"10.1165\/rcmb.2008-0179oc","type":"journal-article","created":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T20:12:48Z","timestamp":1229717568000},"page":"59-68","source":"Crossref","is-referenced-by-count":51,"title":["Matrix Metalloproteinase-9 Deficiency Worsens Lung Injury in a Model of Bronchopulmonary Dysplasia"],"prefix":"10.1093","volume":"41","author":[{"given":"Heikki","family":"Lukkarinen","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Hogmalm","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urpo","family":"Lappalainen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Bry","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,7,1]]},"reference":[{"key":"2026030623271834700_bib1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1165\/rcmb.2002-0166TR","volume":"28","year":"2003","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026030623271834700_bib2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1080\/019021490944232","volume":"31","year":"2005","journal-title":"Exp Lung Res"},{"key":"2026030623271834700_bib3","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1164\/ajrccm.163.7.2011060","volume":"163","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030623271834700_bib4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1084-2756(02)00193-8","volume":"8","year":"2003","journal-title":"Semin Neonatol"},{"key":"2026030623271834700_bib5","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1203\/00006450-199608000-00010","volume":"40","year":"1996","journal-title":"Pediatr Res"},{"key":"2026030623271834700_bib6","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0002-9378(97)70276-X","volume":"177","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"2026030623271834700_bib7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1165\/rcmb.2006-0116OC","volume":"36","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026030623271834700_bib8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1084-2756(02)00190-2","volume":"8","year":"2003","journal-title":"Semin Neonatol"},{"key":"2026030623271834700_bib9","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1542\/peds.113.6.1709","volume":"113","year":"2004","journal-title":"Pediatrics"},{"key":"2026030623271834700_bib10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/ppul.20135","volume":"39","year":"2005","journal-title":"Pediatr Pulmonol"},{"key":"2026030623271834700_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1203\/00006450-200107000-00008","volume":"50","year":"2001","journal-title":"Pediatr Res"},{"key":"2026030623271834700_bib12","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1165\/rcmb.2004-0309OC","volume":"32","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026030623271834700_bib13","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1165\/rcmb.2005-0378OC","volume":"34","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026030623271834700_bib14","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1203\/00006450-200302000-00009","volume":"53","year":"2003","journal-title":"Pediatr Res"},{"key":"2026030623271834700_bib15","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1172\/JCI119792","volume":"100","year":"1997","journal-title":"J Clin Invest"},{"key":"2026030623271834700_bib16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2144\/05381RV01","volume":"38","year":"2005","journal-title":"Biotechniques"},{"key":"2026030623271834700_bib17","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1038\/sj.bjp.0702216","volume":"125","year":"1998","journal-title":"Br J Pharmacol"},{"key":"2026030623271834700_bib18","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.siny.2006.03.004","volume":"11","year":"2006","journal-title":"Semin Fetal Neonatal Med"},{"key":"2026030623271834700_bib19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000088193","volume":"89","year":"2006","journal-title":"Biol Neonate"},{"key":"2026030623271834700_bib20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1203\/01.PDR.0000130658.45564.1F","volume":"56","year":"2004","journal-title":"Pediatr Res"},{"key":"2026030623271834700_bib21","doi-asserted-by":"crossref","first-page":"L535","DOI":"10.1152\/ajplung.00334.2007","volume":"294","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026030623271834700_bib22","doi-asserted-by":"crossref","first-page":"L747","DOI":"10.1152\/ajplung.00415.2001","volume":"283","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026030623271834700_bib23","doi-asserted-by":"crossref","first-page":"11858","DOI":"10.1074\/jbc.275.16.11858","volume":"275","year":"2000","journal-title":"J Biol Chem"},{"key":"2026030623271834700_bib24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1023\/A:1013986627504","volume":"11","year":"2002","journal-title":"Transgenic Res"},{"key":"2026030623271834700_bib25","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1083\/jcb.146.2.517","volume":"146","year":"1999","journal-title":"J Cell Biol"},{"key":"2026030623271834700_bib26","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/(SICI)1097-4652(199602)166:2<413::AID-JCP20>3.0.CO;2-A","volume":"166","year":"1996","journal-title":"J Cell Physiol"},{"key":"2026030623271834700_bib27","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1165\/rcmb.2006-0253SM","volume":"36","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026030623271834700_bib28","doi-asserted-by":"crossref","first-page":"L427","DOI":"10.1152\/ajplung.2001.281.2.L427","volume":"281","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026030623271834700_bib29","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1096\/fj.04-2445com","volume":"18","year":"2004","journal-title":"FASEB J"},{"key":"2026030623271834700_bib30","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1542\/peds.93.5.712","volume":"93","year":"1994","journal-title":"Pediatrics"},{"key":"2026030623271834700_bib31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0378-3782(98)00045-0","volume":"53","year":"1998","journal-title":"Early Hum Dev"},{"key":"2026030623271834700_bib32","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1172\/JCI110957","volume":"72","year":"1983","journal-title":"J Clin Invest"},{"key":"2026030623271834700_bib33","first-page":"1","volume":"7","year":"2001","journal-title":"Curr Opin Crit Care"},{"key":"2026030623271834700_bib34","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1165\/ajrcmb.14.3.8845180","volume":"14","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026030623271834700_bib35","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1189\/jlb.71.5.821","volume":"71","year":"2002","journal-title":"J Leukoc Biol"},{"key":"2026030623271834700_bib36","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1182\/blood.V96.8.2673","volume":"96","year":"2000","journal-title":"Blood"},{"key":"2026030623271834700_bib37","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1096\/fj.03-1412fje","volume":"18","year":"2004","journal-title":"FASEB J"},{"key":"2026030623271834700_bib38","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/sj.cdd.4401209","volume":"10","year":"2003","journal-title":"Cell Death Differ"},{"key":"2026030623271834700_bib39","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2353\/ajpath.2008.071123","volume":"173","year":"2008","journal-title":"Am J Pathol"},{"key":"2026030623271834700_bib40","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1203\/00006450-199803000-00020","volume":"43","year":"1998","journal-title":"Pediatr Res"},{"key":"2026030623271834700_bib41","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1165\/ajrcmb.18.6.3031","volume":"18","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026030623271834700_bib42","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1203\/00006450-198805000-00007","volume":"23","year":"1988","journal-title":"Pediatr Res"},{"key":"2026030623271834700_bib43","doi-asserted-by":"crossref","first-page":"S160","DOI":"10.1164\/ajrccm\/150.6_Pt_2.S160","volume":"150","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030623271834700_bib44","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1126\/science.7233186","volume":"212","year":"1981","journal-title":"Science"},{"key":"2026030623271834700_bib45","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1172\/JCI113970","volume":"83","year":"1989","journal-title":"J Clin Invest"},{"key":"2026030623271834700_bib46","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/0140-6736(91)91443-X","volume":"338","year":"1991","journal-title":"Lancet"},{"key":"2026030623271834700_bib47","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1164\/rccm.200611-1660PP","volume":"175","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030623271834700_bib48","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1161\/hq0701.093685","volume":"21","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026030623271834700_bib49","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1161\/01.RES.0000111527.42357.62","volume":"94","year":"2004","journal-title":"Circ Res"},{"key":"2026030623271834700_bib50","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1083\/jcb.200409115","volume":"169","year":"2005","journal-title":"J Cell Biol"},{"key":"2026030623271834700_bib51","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1067\/mob.2003.215","volume":"188","year":"2003","journal-title":"Am J Obstet Gynecol"}],"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/41\/1\/59\/67068583\/ajrcmb_41_1_59.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/41\/1\/59\/67068583\/ajrcmb_41_1_59.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:29:18Z","timestamp":1772857758000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/41\/1\/59\/8493995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,1]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,7,1]]},"published-print":{"date-parts":[[2009,7,1]]}},"URL":"https:\/\/doi.org\/10.1165\/rcmb.2008-0179oc","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2009,7]]},"published":{"date-parts":[[2009,7,1]]}}}