{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:04:28Z","timestamp":1790460268004,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mutations in the tumor suppressor tuberin (TSC2) are a common factor in the development of lymphangioleiomyomatosis (LAM). LAM is a cystic lung disease that is characterized by the infiltration of smooth muscle\u2013like cells into the pulmonary parenchyma. The mechanism by which the loss of tuberin promotes the development of LAM has yet to be elucidated, although several lines of evidence suggest it is due to the metastasis of tuberin-deficient cells. Here we show that tuberin-null cells become nonadherent and invasive. These nonadherent cells express cleaved forms of \u03b2-catenin. In reporter assays, the \u03b2-catenin products are transcriptionally active and promote MMP7 expression. Invasion by the tuberin-null cells is mediated by MMP7. Examination of LAM tissues shows the expression of cleaved \u03b2-catenin products and MMP7 consistent with a model that tuberin-deficient cells acquire invasive properties through a \u03b2-catenin\u2013dependent mechanism, which may underlie the development of LAM.<\/jats:p>","DOI":"10.1165\/rcmb.2008-0335oc","type":"journal-article","created":{"date-parts":[[2009,12,30]],"date-time":"2009-12-30T22:15:09Z","timestamp":1262211309000},"page":"617-627","source":"Crossref","is-referenced-by-count":17,"title":["The Loss of Tuberin Promotes Cell Invasion through the \u03b2-Catenin Pathway"],"prefix":"10.1093","volume":"43","author":[{"given":"Elizabeth A.","family":"Barnes","sequence":"first","affiliation":[{"name":"University of Washington, Department of Surgery, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi L.","family":"Kenerson","sequence":"additional","affiliation":[{"name":"University of Washington, Department of Surgery, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baldwin C.","family":"Mak","sequence":"additional","affiliation":[{"name":"University of Washington, Department of Surgery, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond S.","family":"Yeung","sequence":"additional","affiliation":[{"name":"University of Washington, Department of Surgery, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,11,1]]},"reference":[{"key":"2026030623234201100_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00000441-200101000-00004","volume":"321","year":"2001","journal-title":"Am J Med Sci"},{"key":"2026030623234201100_bib2","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1086\/301804","volume":"62","year":"1998","journal-title":"Am J Hum Genet"},{"key":"2026030623234201100_bib3","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1073\/pnas.97.11.6085","volume":"97","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026030623234201100_bib4","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1164\/ajrccm.164.8.2104095","volume":"164","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030623234201100_bib5","first-page":"61S","volume":"121","year":"2002","journal-title":"Chest"},{"key":"2026030623234201100_bib6","first-page":"10","year":"1999"},{"key":"2026030623234201100_bib7","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/j.1523-1755.2004.00838.x","volume":"66","year":"2004","journal-title":"Kidney Int"},{"key":"2026030623234201100_bib8","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1464-410X.2004.05046.x","volume":"94","year":"2004","journal-title":"BJU Int"},{"key":"2026030623234201100_bib9","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0272-6386(03)00006-4","volume":"41","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"2026030623234201100_bib10","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1056\/NEJM199610243351704","volume":"335","year":"1996","journal-title":"N Engl J Med"},{"key":"2026030623234201100_bib11","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1164\/ajrccm.151.6.7767554","volume":"151","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030623234201100_bib12","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1164\/rccm.200208-969OC","volume":"167","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030623234201100_bib13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1053\/hupa.2003.50","volume":"34","year":"2003","journal-title":"Hum Pathol"},{"key":"2026030623234201100_bib14","doi-asserted-by":"crossref","first-page":"17462","DOI":"10.1073\/pnas.0407971101","volume":"101","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026030623234201100_bib15","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.yexcr.2004.01.022","volume":"295","year":"2004","journal-title":"Exp Cell Res"},{"key":"2026030623234201100_bib16","doi-asserted-by":"crossref","first-page":"9154","DOI":"10.1073\/pnas.93.17.9154","volume":"93","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026030623234201100_bib17","doi-asserted-by":"crossref","first-page":"11413","DOI":"10.1073\/pnas.91.24.11413","volume":"91","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026030623234201100_bib18","first-page":"7","volume":"7","year":"2001","journal-title":"Curr Protoc Cytom"},{"key":"2026030623234201100_bib19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0002-9440(10)64533-6","volume":"157","year":"2000","journal-title":"Am J Pathol"},{"key":"2026030623234201100_bib20","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.2353\/ajpath.2008.070891","volume":"172","year":"2008","journal-title":"Am J Pathol"},{"key":"2026030623234201100_bib21","doi-asserted-by":"crossref","first-page":"5947","DOI":"10.1074\/jbc.C200473200","volume":"278","year":"2003","journal-title":"J Biol Chem"},{"key":"2026030623234201100_bib22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0002-9440(10)62958-6","volume":"167","year":"2005","journal-title":"Am J Pathol"},{"key":"2026030623234201100_bib23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0014-5793(99)01153-9","volume":"458","year":"1999","journal-title":"FEBS Lett"},{"key":"2026030623234201100_bib24","doi-asserted-by":"crossref","first-page":"16345","DOI":"10.1074\/jbc.M001458200","volume":"275","year":"2000","journal-title":"J Biol Chem"},{"key":"2026030623234201100_bib25","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.272.5264.974","volume":"272","year":"1996","journal-title":"Science"},{"key":"2026030623234201100_bib26","doi-asserted-by":"crossref","first-page":"24735","DOI":"10.1074\/jbc.272.40.24735","volume":"272","year":"1997","journal-title":"J Biol Chem"},{"key":"2026030623234201100_bib27","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1083\/jcb.136.3.693","volume":"136","year":"1997","journal-title":"J Cell Biol"},{"key":"2026030623234201100_bib28","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1126\/science.275.5307.1752","volume":"275","year":"1997","journal-title":"Science"},{"key":"2026030623234201100_bib29","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/18884","volume":"398","year":"1999","journal-title":"Nature"},{"key":"2026030623234201100_bib30","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1038\/sj.onc.1202627","volume":"18","year":"1999","journal-title":"Oncogene"},{"key":"2026030623234201100_bib31","first-page":"1","volume":"78","year":"2006","journal-title":"Birth Defects Res C Embryo Today"},{"key":"2026030623234201100_bib32","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1165\/ajrcmb.20.6.f151","volume":"20","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026030623234201100_bib33","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S0046-8177(97)90061-7","volume":"28","year":"1997","journal-title":"Hum Pathol"},{"key":"2026030623234201100_bib34","doi-asserted-by":"crossref","first-page":"267","DOI":"10.5858\/2000-124-0267-RFAOMM","volume":"124","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"2026030623234201100_bib35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/153537020623100103","volume":"231","year":"2006","journal-title":"Exp Biol Med"},{"key":"2026030623234201100_bib36","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1042\/bj2770277","volume":"277","year":"1991","journal-title":"Biochem J"},{"key":"2026030623234201100_bib37","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1242\/jcs.114.1.111","volume":"114","year":"2001","journal-title":"J Cell Sci"},{"key":"2026030623234201100_bib38","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cell.2006.10.018","volume":"127","year":"2006","journal-title":"Cell"},{"key":"2026030623234201100_bib39","doi-asserted-by":"crossref","first-page":"19185","DOI":"10.1074\/jbc.M414275200","volume":"280","year":"2005","journal-title":"J Biol Chem"},{"key":"2026030623234201100_bib40","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/path.1466","volume":"201","year":"2003","journal-title":"J Pathol"},{"key":"2026030623234201100_bib41","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1165\/rcmb.2005-0374OC","volume":"34","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026030623234201100_bib42","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nature01063","volume":"419","year":"2002","journal-title":"Nature"},{"key":"2026030623234201100_bib43","first-page":"973","volume":"15","year":"2005","journal-title":"Int J Mol Med"},{"key":"2026030623234201100_bib44","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.molcel.2007.12.023","volume":"29","year":"2008","journal-title":"Mol Cell"},{"key":"2026030623234201100_bib45","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.humpath.2007.01.028","volume":"38","year":"2007","journal-title":"Hum Pathol"}],"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/43\/5\/617\/67068164\/ajrcmb_43_5_617.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/43\/5\/617\/67068164\/ajrcmb_43_5_617.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:24:41Z","timestamp":1772857481000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/43\/5\/617\/8493477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,1]]},"references-count":45,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2010,11,1]]},"published-print":{"date-parts":[[2010,11,1]]}},"URL":"https:\/\/doi.org\/10.1165\/rcmb.2008-0335oc","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,11]]},"published":{"date-parts":[[2010,11,1]]}}}