{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:04:31Z","timestamp":1772928271959,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Our previous studies revealed that, in a murine model of asthma, mice that received Fas-deficient T cells developed a prolonged phase of airway inflammation, mucus production, and airway hyperreactivity that failed to resolve even 6 weeks after the last challenge. To investigate how Fas\u2013Fas ligand (FasL) interaction occurs between T cells and other cells in vivo, Gld mice with abnormalities of the FasL signaling pathway were used. The reconstituted mice were made by transferring T cells from B6 or Gld mice to Rag\u2212\/\u2212 or FasL-deficient Rag\u2212\/\u2212 mice. We found that Rag\u2212\/\u2212 mice that received B6 T cells resolved the airway inflammation, whereas FasL-deficient Rag\u2212\/\u2212 mice that received Gld T cells developed a prolonged airway inflammation at Day 28, with decreased IFN-\u03b3 production. Both FasL-deficient Rag\u2212\/\u2212 mice that received B6 T cells and Rag\u2212\/\u2212 mice that received Gld T cells also had completely resolved their airway inflammation by Day 28 after challenge. Interestingly, FasL-deficient Rag\u2212\/\u2212 mice that received Gld T cells eventually resolved airway inflammation at Day 42, with a similar level of IFN-\u03b3 production to that of control group. These results demonstrate that FasL expression on either T cells only or non\u2013T cells only was sufficient for the eventual resolution of airway inflammation, and the prolonged airway inflammation in FasL-deficient Rag\u2212\/\u2212 mice that received Gld T cells was correlated with decreased IFN-\u03b3 production by Gld T cells.<\/jats:p>","DOI":"10.1165\/rcmb.2008-0454oc","type":"journal-article","created":{"date-parts":[[2009,10,23]],"date-time":"2009-10-23T21:29:57Z","timestamp":1256333397000},"page":"342-348","source":"Crossref","is-referenced-by-count":10,"title":["Fas Ligand Expression on T Cells Is Sufficient to Prevent Prolonged Airway Inflammation in a Murine Model of Asthma"],"prefix":"10.1093","volume":"43","author":[{"given":"Jiankun","family":"Tong","sequence":"first","affiliation":[{"name":"Section of Pulmonary and Critical Care Medicine, Department of Medicine"},{"name":"Department of Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan 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