{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:22:50Z","timestamp":1787602970961,"version":"build-2736575974"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mechanical ventilation is a life-saving therapy that can also damage the lungs. Ventilator-induced lung injury (VILI) promotes inflammation and up-regulates matrix metalloproteinases (MMPs). Among these enzymes, MMP-8 is involved in the onset of inflammation by processing different immune mediators. To clarify the role of MMP-8 in a model of VILI and their relevance as a therapeutic target, we ventilated wild-type and MMP-8\u2013deficient mice with low or high pressures for 2 hours. There were no significant differences after low-pressure ventilation between wild-type and knockout animals. However, lack of MMP-8 results in better gas exchange, decreased lung edema and permeability, and diminished histological injury after high-pressure ventilation. Mmp8\u2212\/\u2212 mice had a different immune response to injurious ventilation, with decreased neutrophilic infiltration, lower levels of IFN-\u03b3 and chemokines (LPS-induced CXC chemokine, macrophage inflammatory protein\u20132), and significant increases in anti-inflammatory cytokines (IL-4, IL-10) in lung tissue and bronchoalveolar lavage fluid. There were no differences in MMP-2, MMP-9, or tissue inhibitor of metalloproteinase\u20131 between wild-type and knockout mice. These results were confirmed by showing a similar protective effect in wild-type mice treated with a selective MMP-8 inhibitor. We conclude that MMP-8 promotes acute inflammation after ventilation with high pressures, and its short-term inhibition could be a therapeutic goal to limit VILI.<\/jats:p>","DOI":"10.1165\/rcmb.2009-0034oc","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T00:29:02Z","timestamp":1260232142000},"page":"555-563","source":"Crossref","is-referenced-by-count":58,"title":["Absence or Inhibition of Matrix Metalloproteinase\u20138 Decreases Ventilator-Induced Lung Injury"],"prefix":"10.1093","volume":"43","author":[{"given":"Guillermo M.","family":"Albaiceta","sequence":"first","affiliation":[{"name":"Departments of Biolog\u00eda Funcional"},{"name":"Intensive Care Unit, Hospital Universitario Central de Asturias, Oviedo, Spain; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gutierrez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Bioqu\u00edmica y Biolog\u00eda Molecular, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Garc\u00eda-Prieto","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Hospital Universitario Central de Asturias, Oviedo, Spain; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xose S.","family":"Puente","sequence":"additional","affiliation":[{"name":"Bioqu\u00edmica y Biolog\u00eda Molecular, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Parra","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Hospital Universitario Central de Asturias, Oviedo, Spain; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Astudillo","sequence":"additional","affiliation":[{"name":"Cirug\u00eda y Especialidades M\u00e9dico-Quirurgicas, Universidad de Oviedo, Instituto Universitario de Oncolog\u00eda del Principado de Asturias, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Campestre","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco, Universit\u00e0 \u201cG. d'Annunzio,\u201d Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Bioqu\u00edmica y Biolog\u00eda Molecular, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Gonzalez-Lopez","sequence":"additional","affiliation":[{"name":"Departments of Biolog\u00eda Funcional"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Fueyo","sequence":"additional","affiliation":[{"name":"Departments of Biolog\u00eda Funcional"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Taboada","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Hospital Universitario Central de Asturias, Oviedo, Spain; and"},{"name":"Department of Medicina, Universidad de Oviedo, Instituto Universitario de Oncolog\u00eda del Principado de Asturias, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"L\u00f3pez-Otin","sequence":"additional","affiliation":[{"name":"Bioqu\u00edmica y Biolog\u00eda Molecular, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,11,1]]},"reference":[{"key":"2026030623232752400_bib1","first-page":"646","volume":"50","year":"2005","journal-title":"Respir Care"},{"key":"2026030623232752400_bib2","first-page":"15s","volume":"47","year":"2003","journal-title":"Eur Respir J Suppl"},{"key":"2026030623232752400_bib3","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1126\/science.280.5365.898","volume":"280","year":"1998","journal-title":"Science"},{"key":"2026030623232752400_bib4","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1165\/ajrcmb.25.6.4558f","volume":"25","year":"2001","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026030623232752400_bib5","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","volume":"69","year":"2006","journal-title":"Cardiovasc Res"},{"key":"2026030623232752400_bib6","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00134-005-0043-z","volume":"32","year":"2006","journal-title":"Intensive Care Med"},{"key":"2026030623232752400_bib7","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1164\/ajrccm.154.2.8756805","volume":"154","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030623232752400_bib8","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.humpath.2005.11.023","volume":"37","year":"2006","journal-title":"Hum Pathol"},{"key":"2026030623232752400_bib9","doi-asserted-by":"crossref","first-page":"L535","DOI":"10.1152\/ajplung.00334.2007","volume":"294","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026030623232752400_bib10","doi-asserted-by":"crossref","first-page":"L541","DOI":"10.1152\/ajplung.00290.2002","volume":"284","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026030623232752400_bib11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1152\/physrev.00022.2006","volume":"87","year":"2007","journal-title":"Physiol Rev"},{"key":"2026030623232752400_bib12","doi-asserted-by":"crossref","first-page":"L580","DOI":"10.1152\/ajplung.00270.2005","volume":"291","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026030623232752400_bib13","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.4049\/jimmunol.176.6.3735","volume":"176","year":"2006","journal-title":"J Immunol"},{"key":"2026030623232752400_bib14","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1289\/ehp.10289","volume":"115","year":"2007","journal-title":"Environ Health Perspect"},{"key":"2026030623232752400_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1165\/rcmb.2008-0179OC","volume":"41","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026030623232752400_bib16","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1016\/j.biocel.2007.06.022","volume":"39","year":"2007","journal-title":"Int J Biochem Cell Biol"},{"key":"2026030623232752400_bib17","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/ng1249","volume":"35","year":"2003","journal-title":"Nat Genet"},{"key":"2026030623232752400_bib18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cytogfr.2006.04.001","volume":"17","year":"2006","journal-title":"Cytokine Growth Factor Rev"},{"key":"2026030623232752400_bib19","doi-asserted-by":"crossref","first-page":"7642","DOI":"10.4049\/jimmunol.175.11.7642","volume":"175","year":"2005","journal-title":"J Immunol"},{"key":"2026030623232752400_bib20","first-page":"S96","volume":"34","year":"2008","journal-title":"Intensive Care Med"},{"key":"2026030623232752400_bib21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1165\/rcmb.2007-0315OC","volume":"39","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026030623232752400_bib22","doi-asserted-by":"crossref","first-page":"L599","DOI":"10.1152\/ajplung.00304.2004","volume":"288","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026030623232752400_bib23","doi-asserted-by":"crossref","first-page":"L718","DOI":"10.1152\/ajplung.90298.2008","volume":"295","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026030623232752400_bib24","doi-asserted-by":"crossref","first-page":"L820","DOI":"10.1152\/ajplung.90211.2008","volume":"295","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026030623232752400_bib25","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1172\/JCI0215849","volume":"110","year":"2002","journal-title":"J Clin Invest"},{"key":"2026030623232752400_bib26","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1096\/fj.06-7860com","volume":"21","year":"2007","journal-title":"FASEB J"},{"key":"2026030623232752400_bib27","doi-asserted-by":"crossref","first-page":"9465","DOI":"10.1074\/jbc.M709522200","volume":"283","year":"2008","journal-title":"J Biol Chem"},{"key":"2026030623232752400_bib28","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","volume":"78","year":"1982","journal-title":"J Invest Dermatol"},{"key":"2026030623232752400_bib29","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.bmc.2006.10.047","volume":"15","year":"2007","journal-title":"Bioorg Med Chem"},{"key":"2026030623232752400_bib30","doi-asserted-by":"crossref","first-page":"e312","DOI":"10.1371\/journal.pone.0000312","volume":"2","year":"2007","journal-title":"PLoS One"},{"key":"2026030623232752400_bib31","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1378\/chest.126.6.1802","volume":"126","year":"2004","journal-title":"Chest"},{"key":"2026030623232752400_bib32","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.intimp.2007.02.009","volume":"7","year":"2007","journal-title":"Int Immunopharmacol"},{"key":"2026030623232752400_bib33","doi-asserted-by":"crossref","first-page":"e1601","DOI":"10.1371\/journal.pone.0001601","volume":"3","year":"2008","journal-title":"PLoS One"},{"key":"2026030623232752400_bib34","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1096\/fj.04-3350fje","volume":"19","year":"2005","journal-title":"FASEB J"},{"key":"2026030623232752400_bib35","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1186\/cc5702","volume":"11","year":"2007","journal-title":"Crit Care"},{"key":"2026030623232752400_bib36","doi-asserted-by":"crossref","first-page":"191","DOI":"10.7326\/0003-4819-125-3-199608010-00005","volume":"125","year":"1996","journal-title":"Ann Intern Med"},{"key":"2026030623232752400_bib37","doi-asserted-by":"crossref","first-page":"L225","DOI":"10.1152\/ajplung.00370.2007","volume":"294","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026030623232752400_bib38","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.rmed.2008.09.020","volume":"103","year":"2009","journal-title":"Respir Med"},{"key":"2026030623232752400_bib39","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1001\/jama.282.1.54","volume":"282","year":"1999","journal-title":"JAMA"},{"key":"2026030623232752400_bib40","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0300-483X(89)90045-0","volume":"54","year":"1989","journal-title":"Toxicology"},{"key":"2026030623232752400_bib41","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0006-2952(03)00002-9","volume":"65","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"2026030623232752400_bib42","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1164\/rccm.200607-915OC","volume":"175","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030623232752400_bib43","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1007\/s00134-005-2746-6","volume":"31","year":"2005","journal-title":"Intensive Care Med"},{"key":"2026030623232752400_bib44","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/01.shk.0000180619.06317.2c","volume":"24","year":"2005","journal-title":"Shock"}],"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/43\/5\/555\/67068279\/ajrcmb_43_5_555.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/43\/5\/555\/67068279\/ajrcmb_43_5_555.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:24:21Z","timestamp":1772857461000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/43\/5\/555\/8493559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,1]]},"references-count":44,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2010,11,1]]},"published-print":{"date-parts":[[2010,11,1]]}},"URL":"https:\/\/doi.org\/10.1165\/rcmb.2009-0034oc","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,11]]},"published":{"date-parts":[[2010,11,1]]}}}