{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:01:03Z","timestamp":1791036063527,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Activation of NF-\u03baB in airway epithelium is observed in allergic asthma and is induced by inhalation of numerous infectious and reactive substances. Many of the substances that activate NF-\u03baB in the airway epithelium are also capable of acting as adjuvants to elicit antigen-specific sensitization to concomitantly inhaled protein, thereby circumventing the inherent bias of the lung to promote tolerance to innocuous antigens. We have used a transgenic mouse inducibly expressing a constitutively active mutant of the inhibitor of nuclear factor \u03baB (I\u03baB) kinase \u03b2 (CAIKK\u03b2) that activates NF-\u03baB only in nonciliated airway epithelial cells to test whether activation of this intracellular signaling pathway in this specific cell type is sufficient to establish a pulmonary environment permissive to the development of allergic sensitization to inhaled protein. When airway epithelial CAIKK\u03b2 was transiently expressed in antigen-naive mice only during initial inhalation of ovalbumin, the mice became allergically sensitized to the antigen. As a consequence, subsequent inhalation of ovalbumin alone led to an allergic asthma\u2013like response that included airway hyperresponsiveness to methacholine, eosinophilia, mucus expression, elevated serum levels of antigen-specific IgE and IgG1, and splenic CD4+ T cells that secreted T helper type 2 and type 17 cytokines in response to in vitro antigen restimulation. Furthermore, CD11c+ cells in the mediastinal lymph nodes (MLN) of CAIKK\u03b2-expressing mice displayed significantly elevated levels of activation markers. These data implicate airway epithelial NF-\u03baB activation as a critical modulator of the adaptive immune response to inhaled antigens via the secretion of soluble mediators that affect the capacity of CD11c+ cells to undergo maturation and promote antigen-specific allergic responses.<\/jats:p>","DOI":"10.1165\/rcmb.2010-0106oc","type":"journal-article","created":{"date-parts":[[2010,6,25]],"date-time":"2010-06-25T20:49:57Z","timestamp":1277498997000},"page":"631-638","source":"Crossref","is-referenced-by-count":62,"title":["Airway Epithelial NF-\u03baB Activation Promotes Allergic Sensitization to an Innocuous Inhaled Antigen"],"prefix":"10.1093","volume":"44","author":[{"given":"Jennifer L.","family":"Ather","sequence":"first","affiliation":[{"name":"Department of Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha R.","family":"Hodgkins","sequence":"additional","affiliation":[{"name":"Department of Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne M. W.","family":"Janssen-Heininger","sequence":"additional","affiliation":[{"name":"Department of Pathology, Vermont Lung Center, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew E.","family":"Poynter","sequence":"additional","affiliation":[{"name":"Department of Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,5,1]]},"reference":[{"key":"2026030623215227500_bib1","doi-asserted-by":"crossref","first-page":"4S","DOI":"10.1378\/chest.130.1_suppl.4S","volume":"130","year":"2006","journal-title":"Chest"},{"key":"2026030623215227500_bib2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1365-2222.2008.03118.x","volume":"39","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"2026030623215227500_bib3","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1056\/NEJMra0804579","volume":"360","year":"2009","journal-title":"N Engl J 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