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In an ovalbumin-induced mouse asthma model, mastic significantly inhibited eosinophilia, while reducing airway hyperresponsiveness and suppressing the production of inflammatory cytokines (IL-5 and IL-13) as well as chemokines (eotaxin, eotaxin2, and regulated upon activation, normal T-cell expressed and secreted) in bronchoalveolar lavage fluid. Moreover, mastic potently inhibited eotaxin-induced eosinophil chemotaxis in vitro without influencing eotaxin receptor, chemokine receptor 3, expression. These results suggest that mastic may contribute to the treatment of inflammatory diseases.<\/jats:p>","DOI":"10.1165\/rcmb.2010-0212oc","type":"journal-article","created":{"date-parts":[[2010,9,21]],"date-time":"2010-09-21T00:42:33Z","timestamp":1285029753000},"page":"95-100","source":"Crossref","is-referenced-by-count":17,"title":["Mastic Alleviates Allergic Inflammation in Asthmatic Model Mice by Inhibiting Recruitment of Eosinophils"],"prefix":"10.1093","volume":"45","author":[{"given":"Jianou","family":"Qiao","sequence":"first","affiliation":[{"name":"Respiratory Department, Shanghai Jiao Tong University-Affiliated Ninth People's Hospital, Shanghai, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Cell Signaling and Diseases, School of Life Science and Technology, Tongji University, Shanghai, People's Republic of China; 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