{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:47:22Z","timestamp":1791031642156,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Airway bacterial infections are a major problem in lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. Increased Th2 cytokines, such as IL-13, are observed in lung diseases and may contribute to bacterial infections. How Th2 cytokines affect bacterial infection remains unknown. MUC18, an adhesion molecule shown to be involved in the pathogenesis of malignant melanoma, has been recently identified in airway epithelial cells of patients with COPD. We investigated MUC18 regulation by IL-13 and the role of MUC18 in bacterial adherence to epithelial cells. Human airway tissues, brushed bronchial epithelial cells from normal subjects and subjects with asthma, and epithelial cell lines (e.g., HEK293 cells) were used to study the regulation of MUC18 by IL-13 and the involvement of MUC18 in bacterial (e.g., Mycoplasma pneumoniae [Mp] and nontypeable Haemophilus influenzae [NTHi]) adherence to epithelial cells. Asthmatic bronchial epithelium expressed higher levels of MUC18 than normal bronchial epithelium. IL-13 increased MUC18 in cultured bronchial epithelial cells from normal subjects and particularly from subjects with asthma. IL-13\u2013induced MUC18 expression may be modulated in part through transcription factor specificity protein 1. Overexpression of human MUC18 in HEK293 cells increased cell-associated Mp and NTHi levels. Moreover, MUC18 was shown to directly interact with Mp and NTHi. These results for the first time show that an allergic airway milieu (e.g., IL-13) increases MUC18 expression, which may contribute to increased bacterial infection\/colonization in asthma and other lung diseases.<\/jats:p>","DOI":"10.1165\/rcmb.2010-0384oc","type":"journal-article","created":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T22:02:17Z","timestamp":1295042537000},"page":"606-613","source":"Crossref","is-referenced-by-count":29,"title":["Up-Regulation of MUC18 in Airway Epithelial Cells by IL-13"],"prefix":"10.1093","volume":"44","author":[{"given":"Glenn C.","family":"Simon","sequence":"first","affiliation":[{"name":"Department of Medicine, National Jewish Health, Denver, Colorado; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Health, Denver, Colorado; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Health, Denver, Colorado; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Thaikoottathil","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Health, Denver, Colorado; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell P.","family":"Bowler","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Health, Denver, Colorado; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Barenkamp","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Wei","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Health, Denver, Colorado; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,5,1]]},"reference":[{"key":"2026030623220102400_bib1","doi-asserted-by":"crossref","first-page":"16501","DOI":"10.1074\/jbc.273.26.16501","volume":"273","year":"1998","journal-title":"J Biol Chem"},{"key":"2026030623220102400_bib2","doi-asserted-by":"crossref","first-page":"9891","DOI":"10.1073\/pnas.86.24.9891","volume":"86","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026030623220102400_bib3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.mvr.2009.06.012","volume":"78","year":"2009","journal-title":"Microvasc Res"},{"key":"2026030623220102400_bib4","first-page":"2295","volume":"57","year":"1997","journal-title":"Cancer Res"},{"key":"2026030623220102400_bib5","doi-asserted-by":"crossref","first-page":"8514","DOI":"10.1073\/pnas.90.18.8514","volume":"90","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026030623220102400_bib6","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/(SICI)1097-0215(19971127)73:5<769::AID-IJC26>3.0.CO;2-#","volume":"73","year":"1997","journal-title":"Int J Cancer"},{"key":"2026030623220102400_bib7","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1183\/09031936.03.00102303","volume":"22","year":"2003","journal-title":"Eur Respir J"},{"key":"2026030623220102400_bib8","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1111\/j.1365-2222.2010.03563.x","volume":"40","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"2026030623220102400_bib9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1164\/rccm.200412-1747OC","volume":"172","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030623220102400_bib10","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1164\/rccm.200903-0392OC","volume":"180","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"2026030623220102400_bib11","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/MCP.0b013e32831da894","volume":"15","year":"2009","journal-title":"Curr Opin Pulm Med"},{"key":"2026030623220102400_bib12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1183\/09031936.04.00135703","volume":"24","year":"2004","journal-title":"Eur Respir J"},{"key":"2026030623220102400_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1513\/pats.200512-125SF","volume":"3","year":"2006","journal-title":"Proc Am Thorac Soc"},{"key":"2026030623220102400_bib14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1586\/14787210.4.1.101","volume":"4","year":"2006","journal-title":"Expert Rev Anti Infect Ther"},{"key":"2026030623220102400_bib15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1513\/pats.200707-097TH","volume":"4","year":"2007","journal-title":"Proc Am Thorac Soc"},{"key":"2026030623220102400_bib16","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.4049\/jimmunol.179.6.3995","volume":"179","year":"2007","journal-title":"J Immunol"},{"key":"2026030623220102400_bib17","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1471-2466-10-30","volume":"10","year":"2010","journal-title":"BMC Pulm Med"},{"key":"2026030623220102400_bib18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1164\/ajrccm\/136.1.225","volume":"136","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"2026030623220102400_bib19","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S0002-9440(10)63371-8","volume":"165","year":"2004","journal-title":"Am J Pathol"},{"key":"2026030623220102400_bib20","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1165\/rcmb.2007-0078OC","volume":"38","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026030623220102400_bib21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2500\/ajra.2010.24.3381","volume":"24","year":"2010","journal-title":"Am J Rhinol Allergy"},{"key":"2026030623220102400_bib22","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2222.2004.01885.x","volume":"34","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"2026030623220102400_bib23","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.4049\/jimmunol.174.9.5713","volume":"174","year":"2005","journal-title":"J Immunol"},{"key":"2026030623220102400_bib24","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2334-4-12","volume":"4","year":"2004","journal-title":"BMC Infect Dis"},{"key":"2026030623220102400_bib25","first-page":"6560","volume":"9","year":"2003","journal-title":"Clin Cancer Res"},{"key":"2026030623220102400_bib26","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1086\/382050","volume":"189","year":"2004","journal-title":"J Infect Dis"},{"key":"2026030623220102400_bib27","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/pros.1111","volume":"48","year":"2001","journal-title":"Prostate"},{"key":"2026030623220102400_bib28","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.gastro.2005.05.002","volume":"129","year":"2005","journal-title":"Gastroenterology"},{"key":"2026030623220102400_bib29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1183\/09031936.00103307","volume":"31","year":"2008","journal-title":"Eur Respir J"},{"key":"2026030623220102400_bib30","first-page":"35","volume":"3","year":"1993","journal-title":"Melanoma Res"},{"key":"2026030623220102400_bib31","doi-asserted-by":"crossref","first-page":"7387","DOI":"10.1128\/JB.183.24.7387-7891.2001","volume":"183","year":"2001","journal-title":"J Bacteriol"},{"key":"2026030623220102400_bib32","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.ceb.2006.08.008","volume":"18","year":"2006","journal-title":"Curr Opin Cell Biol"},{"key":"2026030623220102400_bib33","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1074\/jbc.M007065200","volume":"276","year":"2001","journal-title":"J Biol Chem"}],"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/44\/5\/606\/67066350\/ajrcmb_44_5_606.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/44\/5\/606\/67066350\/ajrcmb_44_5_606.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:22:38Z","timestamp":1772857358000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/44\/5\/606\/8493349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,1]]},"references-count":33,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,5,1]]},"published-print":{"date-parts":[[2011,5,1]]}},"URL":"https:\/\/doi.org\/10.1165\/rcmb.2010-0384oc","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.11015956.11973054","asserted-by":"object"}]},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,5]]},"published":{"date-parts":[[2011,5,1]]}}}