{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:43:00Z","timestamp":1791582180086,"version":"4.3.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although a similar prevalence of smoking is evident among patients with asthma and the general population, little is known about the impact of cigarette smoke on the immune inflammatory processes elicited by common environmental allergens. We investigated the impact of exposure to cigarette smoke on house dust mite (HDM)\u2013induced allergic airway inflammation and its consequences for tissue remodeling and lung physiology in mice. BALB\/c mice received intranasal HDMs daily, 5 days per week, for 3 weeks to establish chronic airway inflammation. Subsequently, mice were concurrently exposed to HDMs plus cigarette smoke, 5 days per week, for 2 weeks (HDMs + smoke). We observed significantly attenuated eosinophilia in the bronchoalveolar lavage of mice exposed to HDMs + smoke, compared with animals exposed only to HDMs. A similar activation of CD4 T cells and expression of IL-5, IL-13, and transforming growth factor\u2013\u03b2 was observed between HDM-treated and HDM + smoke\u2013treated animals. Consistent with an effect on eosinophil trafficking, HDMs + smoke exposure attenuated the HDM-induced expression of eotaxin-1 and vascular cell adhesion molecule\u20131, whereas the survival of eosinophils and the numbers of blood eosinophils were not affected. Exposure to cigarette smoke also reduced the activation of B cells and the concentrations of serum IgE. Although the production of mucus decreased, collagen deposition significantly increased in animals exposed to HDMs + smoke, compared with animals exposed only to HDMs. Although airway resistance was unaffected, tissue resistance was significantly decreased in mice exposed to HDMs + smoke. Our findings demonstrate that cigarette smoke affects eosinophil migration without affecting airway resistance or modifying Th2 cell adaptive immunity in a murine model of HDM-induced asthma.<\/jats:p>","DOI":"10.1165\/rcmb.2010-0404oc","type":"journal-article","created":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T23:37:58Z","timestamp":1297467478000},"page":"753-760","source":"Crossref","is-referenced-by-count":47,"title":["Cigarette Smoke Differentially Affects Eosinophilia and Remodeling in a Model of House Dust Mite Asthma"],"prefix":"10.1093","volume":"45","author":[{"given":"Fernando M.","family":"Botelho","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Llop-Guevara","sequence":"additional","affiliation":[{"name":"Medical Sciences Graduate Program, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J.","family":"Trimble","sequence":"additional","affiliation":[{"name":"Medical Sciences Graduate Program, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake K.","family":"Nikota","sequence":"additional","affiliation":[{"name":"Medical Sciences Graduate Program, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla M. 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