{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T21:38:24Z","timestamp":1785101904870,"version":"3.55.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Asbestos causes malignant tumors such as lung cancer and malignant mesothelioma (MM). To determine whether asbestos exposure causes reduction of antitumor immunity, we established an in vitro T-cell line model of low-dose and continuous exposure to asbestos using an human adult T-cell leukemia virus\u20131 immortalized human polyclonal T-cell line, MT-2, and revealed that MT-2 cells exposed continuously to asbestos showed resistance to asbestos-induced apoptosis. In addition, the cells presented reduction of surface CXCR3 chemokine receptor expression and IFN-\u03b3 production. In this study, to confirm that these findings are suitable for clinical translation, surface CXCR3 and IFN-\u03b3 expression were analyzed using freshly isolated human CD4+ T cells derived from healthy donors and patients with pleural plaque (PP) or MM. The results revealed that CXCR3 and IFN-\u03b3 expression in the ex vivo model were reduced in some cases. Additionally, CXCR3 expression in CD4+ T cells from PPs and MMs was significantly reduced compared with that from healthy donors, and CD4+ T cells from patients with MMs exhibited a marked reduction in IFN-\u03b3 mRNA levels after stimulation in vitro. Moreover, CD4+CXCR3+ T cells in lymphocytes from MMs showed a tendency for an inverse correlation with its ligand CXCL10\/IP10 in plasma. These findings show reduction of antitumor immune function in asbestos-exposed patients and indicate that CXCR3, IFN-\u03b3, and CXCL10\/IP10 may be candidates to detect and monitor disease status.<\/jats:p>","DOI":"10.1165\/rcmb.2010-0435oc","type":"journal-article","created":{"date-parts":[[2011,2,26]],"date-time":"2011-02-26T00:12:32Z","timestamp":1298679152000},"page":"795-803","source":"Crossref","is-referenced-by-count":39,"title":["Decreased CXCR3 Expression in CD4+ T Cells Exposed to Asbestos or Derived from Asbestos-Exposed Patients"],"prefix":"10.1093","volume":"45","author":[{"given":"Megumi","family":"Maeda","sequence":"first","affiliation":[{"name":"Department of Hygiene, Kawasaki Medical School, Okayama, Japan"},{"name":"Division of Bioscience, Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University, Okayama, 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