{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:14:19Z","timestamp":1776399259297,"version":"3.51.2"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The low-density lipoprotein receptor\u2013related protein 1 (LRP-1) binds and can internalize a diverse group of ligands, including members of the fibrinolytic pathway, urokinase plasminogen activator (uPA), and its receptor, uPAR. In this study, we characterized the role of LRP-1 in uPAR processing, collagen synthesis, proteolysis, and migration in pleural mesothelial cells (PMCs). When PMCs were treated with the proinflammatory cytokines TNF-\u03b1 and IL-1\u03b2, LRP-1 significantly decreased at the mRNA and protein levels (70 and 90%, respectively; P &amp;lt; 0.05). Consequently, uPA-mediated uPAR internalization was reduced by 80% in the presence of TNF-\u03b1 or IL-1\u03b2 (P &amp;lt; 0.05). In parallel studies, LRP-1 neutralization with receptor-associated protein (RAP) significantly reduced uPA-dependent uPAR internalization and increased uPAR stability in PMCs. LRP-1\u2013deficient cells demonstrated increased uPAR t1\/2 versus LRP-1\u2013expressing PMCs. uPA enzymatic activity was also increased in LRP-1\u2013deficient and neutralized cells, and RAP potentiated uPA-dependent migration in PMCs. Collagen expression in PMCs was also induced by uPA, and the effect was potentiated in RAP-treated cells. These studies indicate that TNF-\u03b1 and IL-1\u03b2 regulate LRP-1 in PMCs and that LRP-1 thereby contributes to a range of pathophysiologically relevant responses of these cells.<\/jats:p>","DOI":"10.1165\/rcmb.2011-0071oc","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T21:01:45Z","timestamp":1314910905000},"page":"196-206","source":"Crossref","is-referenced-by-count":28,"title":["Lipoprotein Receptor\u2013Related Protein 1 Regulates Collagen 1 Expression, Proteolysis, and Migration in Human Pleural Mesothelial Cells"],"prefix":"10.1093","volume":"46","author":[{"given":"Torry A.","family":"Tucker","sequence":"first","affiliation":[{"name":"The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LaTerrica","family":"Williams","sequence":"additional","affiliation":[{"name":"The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Koenig","sequence":"additional","affiliation":[{"name":"The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hema","family":"Kothari","sequence":"additional","affiliation":[{"name":"The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey A.","family":"Komissarov","sequence":"additional","affiliation":[{"name":"The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina","family":"Florova","sequence":"additional","affiliation":[{"name":"The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew P.","family":"Mazar","sequence":"additional","affiliation":[{"name":"The Chemistry of Life Processes Institute and Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy C.","family":"Allen","sequence":"additional","affiliation":[{"name":"The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalil","family":"Bdeir","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Vijaya","family":"Mohan Rao","sequence":"additional","affiliation":[{"name":"The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Idell","sequence":"additional","affiliation":[{"name":"The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,2,1]]},"reference":[{"key":"2026021904134089800_bib1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1172\/JCI200113992","article-title":"Lrp: a multifunctional scavenger and signaling receptor","volume":"108","author":"Herz","year":"2001","journal-title":"J Clin Invest"},{"key":"2026021904134089800_bib2","doi-asserted-by":"crossref","first-page":"21862","DOI":"10.1016\/S0021-9258(20)80620-6","article-title":"Low density lipoprotein receptor-related protein\/alpha 2-macroglobulin receptor mediates cellular uptake of pro-urokinase","volume":"268","author":"Kounnas","year":"1993","journal-title":"J Biol Chem"},{"key":"2026021904134089800_bib3","first-page":"143","article-title":"Urokinase\/urokinase receptor system: internalization\/degradation of urokinase-serpin complexes: mechanism and regulation","volume":"376","author":"Conese","year":"1995","journal-title":"Biol Chem Hoppe Seyler"},{"key":"2026021904134089800_bib4","doi-asserted-by":"crossref","first-page":"e3730","DOI":"10.1371\/journal.pone.0003730","article-title":"Clathrin and lrp-1-independent constitutive endocytosis and recycling of upar","volume":"3","author":"Cortese","year":"2008","journal-title":"PLoS ONE"},{"key":"2026021904134089800_bib5","doi-asserted-by":"crossref","first-page":"40499","DOI":"10.1074\/jbc.M207172200","article-title":"Binding of urokinase to low density lipoprotein-related receptor (lrp) regulates vascular smooth muscle cell contraction","volume":"277","author":"Nassar","year":"2002","journal-title":"J Biol Chem"},{"key":"2026021904134089800_bib6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0925-4773(96)00515-1","article-title":"Embryo implantation in mouse: fetomaternal coordination in the pattern of expression of upa, upar, pai-1 and alpha 2mr\/lrp genes","volume":"56","author":"Teesalu","year":"1996","journal-title":"Mech Dev"},{"key":"2026021904134089800_bib7","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1083\/jcb.131.6.1609","article-title":"Alpha-2 macroglobulin receptor\/ldl receptor-related protein(lrp)-dependent internalization of the urokinase receptor","volume":"131","author":"Conese","year":"1995","journal-title":"J Cell Biol"},{"key":"2026021904134089800_bib8","doi-asserted-by":"crossref","first-page":"25668","DOI":"10.1016\/S0021-9258(18)47301-2","article-title":"Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor\/low density lipoprotein receptor-related protein: evidence that the urokinase receptor protects pro-urokinase against binding to the endocytic receptor","volume":"269","author":"Nykjaer","year":"1994","journal-title":"J Biol Chem"},{"key":"2026021904134089800_bib9","doi-asserted-by":"crossref","first-page":"14372","DOI":"10.1074\/jbc.272.22.14372","article-title":"Embryonic fibroblasts that are genetically deficient in low density lipoprotein receptor-related protein demonstrate increased activity of the urokinase receptor system and accelerated migration on vitronectin","volume":"272","author":"Weaver","year":"1997","journal-title":"J Biol Chem"},{"key":"2026021904134089800_bib10","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1055\/s-2007-999053","article-title":"The urokinase receptor and cell migration","volume":"22","author":"Blasi","year":"1996","journal-title":"Semin Thromb Hemost"},{"key":"2026021904134089800_bib11","doi-asserted-by":"crossref","first-page":"7412","DOI":"10.1074\/jbc.274.11.7412","article-title":"The very low density lipoprotein receptor regulates urokinase receptor catabolism and breast cancer cell motility in vitro","volume":"274","author":"Webb","year":"1999","journal-title":"J Biol Chem"},{"key":"2026021904134089800_bib12","doi-asserted-by":"crossref","first-page":"27053","DOI":"10.1074\/jbc.272.43.27053","article-title":"Regulation of single chain urokinase binding, internalization, and degradation by a plasminogen activator inhibitor 1-derived peptide","volume":"272","author":"Zhang","year":"1997","journal-title":"J Biol Chem"},{"key":"2026021904134089800_bib13","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1091\/mbc.12.5.1467","article-title":"Direct binding of occupied urokinase receptor (upar) to ldl receptor-related protein is required for endocytosis of upar and regulation of cell surface urokinase activity","volume":"12","author":"Czekay","year":"2001","journal-title":"Mol Biol Cell"},{"key":"2026021904134089800_bib14","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1093\/emboj\/16.10.2610","article-title":"Recycling of the urokinase receptor upon internalization of the upa:Serpin complexes","volume":"16","author":"Nykjaer","year":"1997","journal-title":"EMBO J"},{"key":"2026021904134089800_bib15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1023\/A:1006914800447","article-title":"Posttranscriptional regulation of urokinase receptor gene expression in human lung carcinoma and mesothelioma cells in vitro","volume":"199","author":"Shetty","year":"1999","journal-title":"Mol Cell Biochem"},{"key":"2026021904134089800_bib16","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1165\/ajrcmb.15.1.8679225","article-title":"Differential expression of the urokinase receptor in fibroblasts from normal and fibrotic human lungs","volume":"15","author":"Shetty","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026021904134089800_bib17","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1165\/rcmb.2009-0046OC","article-title":"Posttranscriptional regulation of plasminogen activator inhibitor-1 expression in human pleural mesothelial cells","volume":"43","author":"Shetty","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026021904134089800_bib18","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1165\/rcmb.2008-0433OC","article-title":"The urokinase receptor supports tumorigenesis of human malignant pleural mesothelioma cells","volume":"42","author":"Tucker","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026021904134089800_bib19","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1164\/ajrccm\/139.1.199","article-title":"Pleural mesothelial cells stimulated by asbestos release chemotactic activity for neutrophils in vitro","volume":"139","author":"Antony","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"2026021904134089800_bib20","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1034\/j.1399-3003.2000.01515.x","article-title":"Tissue factor pathway inhibitor expression by human pleural mesothelial and mesothelioma cells","volume":"15","author":"Bajaj","year":"2000","journal-title":"Eur Respir J"},{"key":"2026021904134089800_bib21","doi-asserted-by":"crossref","first-page":"L25","DOI":"10.1152\/ajplung.00118.2006","article-title":"Intrapleural activation, processing, efficacy, and duration of protection of single-chain urokinase in evolving tetracycline-induced pleural injury in rabbits","volume":"292","author":"Idell","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026021904134089800_bib22","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1242\/jcs.029769","article-title":"Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins","volume":"121","author":"Tang","year":"2008","journal-title":"J Cell Sci"},{"key":"2026021904134089800_bib23","doi-asserted-by":"crossref","first-page":"8502","DOI":"10.1074\/jbc.273.14.8502","article-title":"Binding of urokinase-type plasminogen activator to its receptor in mcf-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility","volume":"273","author":"Nguyen","year":"1998","journal-title":"J Biol Chem"},{"key":"2026021904134089800_bib24","first-page":"L382","article-title":"Pleural mesothelial cell response to inflammation: tumor necrosis factor-induced mitogenesis and collagen synthesis","volume":"265","author":"Owens","year":"1993","journal-title":"Am J Physiol"},{"key":"2026021904134089800_bib25","doi-asserted-by":"crossref","first-page":"H2204","DOI":"10.1152\/ajpheart.00027.2008","article-title":"Erectile dysfunction in the type ii diabetic db\/db mouse: impaired venoocclusion with altered cavernosal vasoreactivity and matrix","volume":"294","author":"Luttrell","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026021904134089800_bib26","first-page":"L972","article-title":"Urokinase receptor in human malignant mesothelioma cells: role in tumor cell mitogenesis and proteolysis","volume":"268","author":"Shetty","year":"1995","journal-title":"Am J Physiol"},{"key":"2026021904134089800_bib27","first-page":"105","article-title":"Interleukin-1beta-induced expression of the urokinase-type plasminogen activator receptor and its co-localization with mmps in human articular chondrocytes","volume":"19","author":"Schwab","year":"2004","journal-title":"Histol Histopathol"},{"key":"2026021904134089800_bib28","doi-asserted-by":"crossref","first-page":"11197","DOI":"10.1523\/JNEUROSCI.2709-06.2006","article-title":"The low-density lipoprotein receptor-related protein is a pro-survival receptor in schwann cells: possible implications in peripheral nerve injury","volume":"26","author":"Campana","year":"2006","journal-title":"J Neurosci"},{"key":"2026021904134089800_bib29","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/bbrc.2001.5728","article-title":"Il-1beta down-regulates tissue-type plasminogen activator by up-regulating low-density lipoprotein receptor-related protein in aml 12 cells","volume":"288","author":"Noguchi","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"2026021904134089800_bib30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1046\/j.1523-1755.2001.00778.x","article-title":"Adenovirus-mediated transfer of the 39 kd receptor-associated protein increases fibrinolytic capacity","volume":"60","author":"Goedde","year":"2001","journal-title":"Kidney Int"},{"key":"2026021904134089800_bib31","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1128\/MCB.02238-07","article-title":"Lrp-1 silencing prevents malignant cell invasion despite increased pericellular proteolytic activities","volume":"28","author":"Dedieu","year":"2008","journal-title":"Mol Cell Biol"},{"key":"2026021904134089800_bib32","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1083\/jcb.200207070","article-title":"Regulation of rac1 activation by the low density lipoprotein receptor-related protein","volume":"159","author":"Ma","year":"2002","journal-title":"J Cell Biol"},{"key":"2026021904134089800_bib33","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0014-5793(94)01032-3","article-title":"Human urokinase receptor expression is inhibited by amiloride and induced by tumor necrosis factor and phorbol ester in colon cancer cells","volume":"353","author":"Wang","year":"1994","journal-title":"FEBS Lett"},{"key":"2026021904134089800_bib34","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1164\/ajrccm.154.3.8810593","article-title":"Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome","volume":"154","author":"Goodman","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"2026021904134089800_bib35","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1046\/j.1523-1755.1999.00244.x","article-title":"Fibrinolytic activity of human mesothelial cells is counteracted by rapid uptake of tissue-type plasminogen activator","volume":"55","author":"Sitter","year":"1999","journal-title":"Kidney Int"},{"key":"2026021904134089800_bib36","doi-asserted-by":"crossref","first-page":"7824","DOI":"10.1038\/sj.onc.1205893","article-title":"Modulation of invasive properties of human glioblastoma cells stably expressing amino-terminal fragment of urokinase-type plasminogen activator","volume":"21","author":"Mohanam","year":"2002","journal-title":"Oncogene"},{"key":"2026021904134089800_bib37","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/jcp.1041650114","article-title":"Plasminogen activators augment endothelial cell organization in vitro by two distinct pathways","volume":"165","author":"Schnaper","year":"1995","journal-title":"J Cell Physiol"},{"key":"2026021904134089800_bib38","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.4049\/jimmunol.163.11.6193","article-title":"Urokinase receptor (cd87) aggregation triggers phosphoinositide hydrolysis and intracellular calcium mobilization in mononuclear phagocytes","volume":"163","author":"Sitrin","year":"1999","journal-title":"J Immunol"},{"key":"2026021904134089800_bib39","doi-asserted-by":"crossref","first-page":"42366","DOI":"10.1074\/jbc.M207705200","article-title":"Low density lipoprotein (ldl) receptor-related protein 1b impairs urokinase receptor regeneration on the cell surface and inhibits cell migration","volume":"277","author":"Li","year":"2002","journal-title":"J Biol Chem"},{"key":"2026021904134089800_bib40","doi-asserted-by":"crossref","first-page":"46932","DOI":"10.1074\/jbc.M207494200","article-title":"The cleavage of the urokinase receptor regulates its multiple functions","volume":"277","author":"Montuori","year":"2002","journal-title":"J Biol Chem"},{"key":"2026021904134089800_bib41","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1073\/pnas.022652999","article-title":"The fibrinolytic receptor for urokinase activates the g protein-coupled chemotactic receptor fprl1\/lxa4r","volume":"99","author":"Resnati","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026021904134089800_bib42","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1091\/mbc.e06-10-0912","article-title":"Urokinase receptor cleavage: a crucial step in fibroblast-to-myofibroblast differentiation","volume":"18","author":"Bernstein","year":"2007","journal-title":"Mol Biol Cell"},{"key":"2026021904134089800_bib43","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1160\/TH05-06-0457","article-title":"Direct interaction of the kringle domain of urokinase-type plasminogen activator (upa) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activation","volume":"95","author":"Tarui","year":"2006","journal-title":"Thromb Haemost"},{"key":"2026021904134089800_bib44","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1161\/01.ATV.17.11.2848","article-title":"Induction of vascular smc proliferation by urokinase indicates a novel mechanism of action in vasoproliferative disorders","volume":"17","author":"Kanse","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026021904134089800_bib45","doi-asserted-by":"crossref","first-page":"12595","DOI":"10.1074\/jbc.M109.008581","article-title":"A cleavage-resistant urokinase plasminogen activator receptor exhibits dysregulated cell-surface clearance","volume":"285","author":"Nieves","year":"2010","journal-title":"J Biol Chem"},{"key":"2026021904134089800_bib46","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1161\/01.ATV.18.5.693","article-title":"Binding of human urokinase-type plasminogen activator to its receptor: residues involved in species specificity and binding","volume":"18","author":"Quax","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026021904134089800_bib47","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.4049\/jimmunol.179.9.6043","article-title":"Tgf-beta1 induces progressive pleural scarring and subpleural fibrosis","volume":"179","author":"Decologne","year":"2007","journal-title":"J Immunol"},{"key":"2026021904134089800_bib48","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1177\/089686080802803s18","article-title":"Transforming growth factor {beta}1 induces epithelial-mesenchymal transition by activating the jnk-smad3 pathway in rat peritoneal mesothelial cells","volume":"28","author":"Liu","year":"2008","journal-title":"Perit Dial Int"},{"key":"2026021904134089800_bib49","doi-asserted-by":"crossref","first-page":"L115","DOI":"10.1152\/ajplung.90587.2008","article-title":"Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to tgf-beta1 in vitro","volume":"297","author":"Nasreen","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026021904134089800_bib50","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1165\/ajrcmb.15.2.8703482","article-title":"Plasmin regulates the activation of cell-associated latent tgf-beta 1 secreted by rat alveolar macrophages after in vivo bleomycin injury","volume":"15","author":"Khalil","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026021904134089800_bib51","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/jcp.1041570312","article-title":"Plasminogen-dependent activation of latent transforming growth factor beta (tgf beta) by growing cultures of osteoblast-like cells","volume":"157","author":"Yee","year":"1993","journal-title":"J Cell Physiol"},{"key":"2026021904134089800_bib52","doi-asserted-by":"crossref","first-page":"e448","DOI":"10.1371\/journal.pone.0000448","article-title":"Lrp1 functions as an atheroprotective integrator of tgfbeta and pdfg signals in the vascular wall: implications for marfan syndrome","volume":"2","author":"Boucher","year":"2007","journal-title":"PLoS ONE"}],"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/46\/2\/196\/66898693\/ajrcmb_46_2_196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/46\/2\/196\/66898693\/ajrcmb_46_2_196.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:13:55Z","timestamp":1771492435000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/46\/2\/196\/8483617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,1]]},"references-count":52,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,2,1]]},"published-print":{"date-parts":[[2012,2,1]]}},"URL":"https:\/\/doi.org\/10.1165\/rcmb.2011-0071oc","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2012,2]]},"published":{"date-parts":[[2012,2,1]]}}}