{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:48:54Z","timestamp":1790840934883,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and usually fatal form of interstitial lung disease (ILD). The precise molecular mechanisms of IPF remain poorly understood. However, analyses of mice receiving bleomycin (BLM) as a model of IPF established the importance of preceding inflammation for the formation of fibrosis. Periostin is a recently characterized matricellular protein involved in modulating cell functions. We recently found that periostin is highly expressed in the lung tissue of patients with IPF, suggesting that it may play a role in the process of pulmonary fibrosis. To explore this possibility, we administered BLM to periostin-deficient mice, and they subsequently showed a reduction of pulmonary fibrosis. We next determined whether this result was caused by a decrease in the preceding recruitment of neutrophils and macrophages in the lungs because of the lower production of chemokines and proinflammatory cytokines. We performed an in vitro analysis of chemokine production in lung fibroblasts, which indicated that periostin-deficient fibroblasts produced few or no chemokines in response to TNF-\u03b1 compared with control samples, at least partly explaining the lack of inflammatory response and, therefore, fibrosis after BLM administration to periostin-deficient mice. In addition, we confirmed that periostin is highly expressed in the lung tissue of chemotherapeutic-agent\u2013induced ILD as well as of patients with IPF. Taking these results together, we conclude that periostin plays a unique role as an inducer of chemokines to recruit neutrophils and macrophages important in the process of pulmonary fibrosis in BLM-administered model mice. Our results suggest a therapeutic potential for periostin in IPF and drug-induced ILD.<\/jats:p>","DOI":"10.1165\/rcmb.2011-0115oc","type":"journal-article","created":{"date-parts":[[2012,1,13]],"date-time":"2012-01-13T01:32:58Z","timestamp":1326418378000},"page":"677-686","source":"Crossref","is-referenced-by-count":145,"title":["Periostin, a Matricellular Protein, Plays a Role in the Induction of Chemokines in Pulmonary Fibrosis"],"prefix":"10.1093","volume":"46","author":[{"given":"Masaru","family":"Uchida","sequence":"first","affiliation":[{"name":"Division of Medical Biochemistry, Department of Biomolecular Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Division of Medical Biochemistry, Department of Biomolecular Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichiro","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Arima","sequence":"additional","affiliation":[{"name":"Division of Medical Biochemistry, Department of Biomolecular Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Division of Medical Biochemistry, Department of Biomolecular Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Medical Biochemistry, Department of Biomolecular Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Division of Respirology, Neurology, and Rheumatology, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn K.","family":"Ahlfeld","sequence":"additional","affiliation":[{"name":"Program in Developmental Biology and Neonatal Medicine, Herman B. 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