{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:19:36Z","timestamp":1789690776644,"version":"4.0.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recent studies suggest that airway smooth muscle remodeling is an early event in the course of asthma. Little is known of the effects of long-term antigen avoidance and inhaled corticosteroids on chronically established airway remodeling. We sought to measure the effects of inhaled corticosteroids and antigen avoidance on airway remodeling in the peripheral airways of horses with heaves, a naturally occurring asthma-like disease. Heaves-affected adult horses with ongoing airway inflammation and bronchoconstriction were treated with fluticasone propionate (with and without concurrent antigen avoidance) (n = 6) or with antigen avoidance alone (n = 5). Lung function and bronchoalveolar lavage were performed at multiple time points, and peripheral lung biopsies were collected before and after 6 and 12 months of treatment. Lung function improved more quickly with inhaled corticosteroids, but eventually normalized in both groups. Inflammation was better controlled with antigen avoidance. During the study period, corrected smooth muscle mass decreased from 12.1 \u00b1 2.8 \u00d7 10\u22123 and 11.3 \u00b1 1.2 \u00d7 10\u22123 to 8.3 \u00b1 1.4 \u00d7 10\u22123 and 7.9 \u00b1 1.0 \u00d7 10\u22123 in the antigen avoidance and fluticasone groups, respectively (P = 0.03). At 6 months, smooth muscle mass was significantly smaller compared with baseline only in the fluticasone-treated animals. The subepithelial collagen area was lower at 12 months than at baseline in both groups. During the study period, airway smooth muscle remodeling decreased by approximately 30% in both groups, although the decrease was faster in horses receiving inhaled corticosteroids. Inhaled corticosteroids may accelerate the reversal of smooth muscle remodeling, even if airway inflammation is better controlled with antigen avoidance.<\/jats:p>","DOI":"10.1165\/rcmb.2011-0363oc","type":"journal-article","created":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T12:27:57Z","timestamp":1340368077000},"page":"589-596","source":"Crossref","is-referenced-by-count":96,"title":["Corticosteroids and Antigen Avoidance Decrease Airway Smooth Muscle Mass in an Equine Asthma Model"],"prefix":"10.1093","volume":"47","author":[{"given":"Mathilde","family":"Leclere","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Universit\u00e9 de Montr\u00e9al, Saint-Hyacinthe, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"Lavoie-Lamoureux","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Universit\u00e9 de Montr\u00e9al, Saint-Hyacinthe, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Joubert","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Anatomopathologie et Cytologie, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, H\u00f4pital Laval, Montreal, Quebec, Canada; 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