{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:19:44Z","timestamp":1790403584581,"version":"4.1.0"},"reference-count":148,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute lung injury (ALI) is a syndrome marked by increased permeability across the pulmonary epithelium resulting in pulmonary edema. Recent evidence suggests that members of the human epidermal growth factor receptor (HER) family are activated in alveolar epithelial cells during ALI and regulate alveolar epithelial barrier function. These tyrosine kinase receptors, which also participate in the pathophysiology of pulmonary epithelial malignancies, regulate cell growth, differentiation, and migration as well as cell\u2013cell adhesion, all processes that influence epithelial injury and repair. In this review we outline mechanisms of epithelial injury and repair in ALI, activation patterns of this receptor family in pulmonary epithelial cells as a consequence injury, how receptor activation alters alveolar permeability, and the possible intracellular signaling pathways involved. Finally, we propose a theoretical model for how HER-mediated modulation of alveolar permeability might affect lung injury and repair. Understanding how these receptors signal has direct therapeutic implications in lung injury and other diseases characterized by altered epithelial barrier function.<\/jats:p>","DOI":"10.1165\/rcmb.2012-0100tr","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T18:40:40Z","timestamp":1339094440000},"page":"395-404","source":"Crossref","is-referenced-by-count":66,"title":["Human Epidermal Growth Factor Receptor Signaling in Acute Lung Injury"],"prefix":"10.1093","volume":"47","author":[{"given":"James H.","family":"Finigan","sequence":"first","affiliation":[{"name":"Division of Oncology, Department of Medicine"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, and"},{"name":"Division of Pulmonary Sciences and Critical Care Medicine, Departments of Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory P.","family":"Downey","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, and"},{"name":"Division of Pulmonary Sciences and Critical Care Medicine, Departments of Medicine and"},{"name":"Integrated Department of Immunology, University of Colorado, Aurora, Colorado"},{"name":"Program in Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Kern","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Medicine"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, and"},{"name":"Division of Pulmonary Sciences and Critical Care Medicine, Departments of Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"2026021904154213700_bib1","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa050333","article-title":"Incidence and outcomes of acute lung injury","volume":"353","author":"Rubenfeld","year":"2005","journal-title":"N Engl J Med"},{"key":"2026021904154213700_bib2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1165\/rcmb.2008-0348TR","article-title":"Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury","volume":"40","author":"Zemans","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026021904154213700_bib3","doi-asserted-by":"crossref","first-page":"L1002","DOI":"10.1152\/ajplung.90555.2008","article-title":"Activated protein C protects against ventilator-induced pulmonary capillary leak","volume":"296","author":"Finigan","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026021904154213700_bib4","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1056\/NEJM200005043421806","article-title":"The acute respiratory distress syndrome","volume":"342","author":"Ware","year":"2000","journal-title":"N Engl J Med"},{"key":"2026021904154213700_bib5","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1172\/JCI115388","article-title":"Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin","volume":"88","author":"Wiener-Kronish","year":"1991","journal-title":"J Clin Invest"},{"key":"2026021904154213700_bib6","first-page":"56","article-title":"What have anatomic and pathologic studies taught us about acute lung injury and acute respiratory distress syndrome?","volume":"14","author":"Capelozzi","year":"2008","journal-title":"Curr Opin Crit Care"},{"key":"2026021904154213700_bib7","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1164\/ajrccm.149.3.7509706","article-title":"The American-European Consensus Conference on ARDS. 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