{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T23:59:08Z","timestamp":1772927948441,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Asthma is a chronic airway inflammatory disease typically associated with T helper cell type 2 (Th2) cytokines. IL-32, first reported as an inducer of tumor necrosis factor (TNF)-\u03b1, is an inflammatory cytokine involved in various autoinflammatory diseases, viral infection, and cancer-related inflammation. However, the role of IL-32\u03b3 in asthma has not been clearly elucidated. In this study, the levels of IL-32\u03b3 in sputum from patients with asthma were measured by ELISA, and IL-32\u03b3 function was investigated in murine models of asthma with human IL-32\u03b3\u2013overexpressed transgenic (IL-32\u03b3 TG) mice. The therapeutic effect of recombinant IL-32\u03b3 (rIL-32\u03b3) on allergic inflammation was also evaluated through bronchoalveolar lavage fluid analysis and histopathologic examinations. Sputum IL-32\u03b3 levels from patients with asthma were lower than those from healthy control subjects. In an acute mouse model of asthma, IL-32\u03b3 TG mice exhibited significantly reduced airway inflammation compared with that in wild-type mice. The production of Th1 cytokines, such as TNF-\u03b1 and IFN-\u03b3, and Th2 cytokines, such as IL-4, IL-5, and IL-13, was decreased in the lungs of IL-32\u03b3TG mice. On the contrary, the expression of IL-10 and IL-10\u2013producing CD11b+ monocytic cells was significantly increased in the lungs of ovalbumin-sensitized IL-32\u03b3 TG mice. In addition, rIL-32\u03b3 treatment revealed a suppressive effect on the airway inflammation in a chronic mouse model of asthma. The results of this study suggest that IL-32\u03b3 may have a preventive role in the development of allergic airway inflammation and could be a potential novel therapeutic target for bronchial asthma.<\/jats:p>","DOI":"10.1165\/rcmb.2013-0234oc","type":"journal-article","created":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T16:16:46Z","timestamp":1401639406000},"page":"1021-1030","source":"Crossref","is-referenced-by-count":27,"title":["Interleukin-32\u03b3 Suppresses Allergic Airway Inflammation in Mouse Models of Asthma"],"prefix":"10.1093","volume":"50","author":[{"given":"Bo-Ram","family":"Bang","sequence":"first","affiliation":[{"name":"Asan Institute for Life Science, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyouk-Soo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Cytokine Immunology, Institute of Biomedical Science and Technology, College of Medicine, Konkuk University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun-Young","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Da","family":"Choi","sequence":"additional","affiliation":[{"name":"Laboratory of Cytokine Immunology, Institute of Biomedical Science and Technology, College of Medicine, Konkuk University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyong Hwa","family":"Hong","sequence":"additional","affiliation":[{"name":"Asan Institute for Life Science, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunjoo","family":"Park","sequence":"additional","affiliation":[{"name":"Asan Institute for Life Science, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Bum","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Bom","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You Sook","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 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