{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:16:18Z","timestamp":1791256578570,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by myofibroblast proliferation and extracellular-matrix accumulation. IPF typically starts in subpleural lung regions, and recent studies suggest that pleural mesothelial cells play a role in the onset of the disease. The transition of mesothelial cells into myofibroblasts (mesothelio\u2013mesenchymal transition) is induced by the profibrotic cytokine, transforming growth factor (TGF)-\u03b21, and is thought to play a role in the development and progression of IPF. The Mothers Against Decapentaplegic homolog (Smad)-dependent pathway is the main TGF-\u03b21 pathway involved in fibrosis. \u03b1B-crystallin is constitutively expressed in the lungs, and is inducible by stress, acts as a chaperon, and is known to play a role in cell cytoskeleton architecture. We recently showed that the lack of \u03b1B-crystallin hampered TGF-\u03b21 signaling by favoring Smad4 monoubiquitination and nuclear export. We demonstrate here, for the first time, that \u03b1B-crystallin is strongly overexpressed in the pleura of fibrotic lungs from patients with IPF and in rodent models of pleural\/subpleural fibrosis. \u03b1B-crystallin\u2013deficient mice are protected from pleural\/subpleural fibrosis induced by the transient adenoviral-mediated overexpression of TGF-\u03b21 or the intrapleural injection of bleomycin combined with carbon particles. We show that \u03b1B-crystallin inhibition hampers Smad4 nuclear localization in pleural mesothelial cells and the consequent characteristics of mesothelio\u2013mesenchymal transition. \u03b1B-crystallin\u2013deficient mesothelial cells fail to acquire the properties of myofibroblasts, thus limiting their migration in vivo and the progression of fibrosis in the lung parenchyma. In conclusion, our work demonstrates that \u03b1B-crystallin may be a key target for the development of specific drugs in the treatment of IPF.<\/jats:p>","DOI":"10.1165\/rcmb.2014-0011oc","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T13:07:31Z","timestamp":1405602451000},"page":"244-252","source":"Crossref","is-referenced-by-count":22,"title":["Antifibrotic Role of \u03b1B-Crystallin Inhibition in Pleural and Subpleural Fibrosis"],"prefix":"10.1093","volume":"52","author":[{"given":"Pierre-Simon","family":"Bellaye","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U866 \u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Dijon, France"},{"name":"Faculty of Medicine and Pharmacy, University of Burgundy, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Burgy","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U866 \u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Dijon, France"},{"name":"Faculty of Medicine and Pharmacy, University of Burgundy, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Colas","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U866 \u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Dijon, France"},{"name":"Faculty of Medicine and Pharmacy, University of Burgundy, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Fabre","sequence":"additional","affiliation":[{"name":"St. Vincent\u2019s University Hospital, Elm Park, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Marchal-Somme","sequence":"additional","affiliation":[{"name":"INSERM U700, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Crestani","sequence":"additional","affiliation":[{"name":"INSERM U700, Paris, France"},{"name":"Universit\u00e9 Paris Diderot, P\u00f4les de Recherche et d'Enseignement Sup\u00e9rieur (PRES) Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"Facult\u00e9 de M\u00e9decine Bichat, Paris Assistance Publique des H\u00f4pitaux de Paris (APHP), H\u00f4pital Bichat, Service de Pneumologie A, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kolb","sequence":"additional","affiliation":[{"name":"Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada; 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