{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T04:07:58Z","timestamp":1770869278458,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study investigated whether hypoxia-inducible factor (HIF)-1 influences postnatal vascularization and alveologenesis in mice and whether stable (constitutive-active) HIF could prevent hyperoxia-induced lung injury. We assessed postnatal vessel and alveolar formation in transgenic mice, expressing a stable, constitutive-active, HIF1\u03b1-subunit (HIF-1\u03b1\u0394ODD) in the distal lung epithelium. In addition, we compared lung function, histology, and morphometry of neonatal transgenic and wild-type mice subjected to hyperoxia. We found that postnatal lungs of HIF-1\u03b1\u0394ODD mice had a greater peripheral vessel density and displayed advanced alveolarization compared with control lungs. Stable HIF-1\u03b1 expression was associated with increased postnatal expression of angiogenic factors, including vascular endothelial growth factor, angiopoietins 1 and 2, Tie2, and Ephrin B2 and B4. Hyperoxia-exposed neonatal HIF-1\u03b1\u0394ODD mice exhibited worse lung function but had similar histological and surfactant abnormalities compared with hyperoxia-exposed wild-type controls. In conclusion, expression of constitutive-active HIF-1\u03b1 in the lung epithelium was associated with increased postnatal vessel growth via up-regulation of angiogenic factors. The increase in postnatal vasculature was accompanied by enhanced alveolar formation. However, stable HIF-1\u03b1 expression in the distal lung did not prevent hyperoxia-induced lung injury in neonates but instead worsened lung function.<\/jats:p>","DOI":"10.1165\/rcmb.2014-0037oc","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T14:30:45Z","timestamp":1409668245000},"page":"448-458","source":"Crossref","is-referenced-by-count":23,"title":["Hypoxia-Inducible Factor-1 Stimulates Postnatal Lung Development but Does Not Prevent O2-Induced Alveolar Injury"],"prefix":"10.1093","volume":"52","author":[{"given":"Jeroen","family":"Tibboel","sequence":"first","affiliation":[{"name":"Department of Physiology and Experimental Medicine, Hospital for Sick Children, Toronto, Canada"},{"name":"Department of Pediatrics, Erasmus University Medical Center \u2013 Sophia Children\u2019s Hospital, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freek 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