{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:18:17Z","timestamp":1788805097928,"version":"build-2803163510"},"reference-count":88,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute lung injury (ALI), which presents as acute respiratory failure, is a major clinical problem that requires aggressive care, and patients who require prolonged oxygen exposure are at risk of developing this disease. Although molecular determinants of ALI have been reported, the molecules involved in disease catabasis associated with oxygen toxicity have not been well studied. It has been reported that lung mucosa is rich in omega-3 fatty acid dicosahexanoic acid (DHA), which has antiinflammatory properties. Aspirin-triggered resolvin D1 (AT-RvD1) is a potent proresolution metabolite of DHA that can curb the inflammatory effects in various acute injuries, yet the effect of AT-RvD1 on hyperoxic acute lung injury (HALI) or in the oxygen toxicity setting in general has not been investigated. The effects of AT-RvD1 on HALI were determined for the first time in 8- to 10-week-old C57BL\/6 mice that were exposed to hyperoxia (\u226595% O2) for 48 hours. Mice were given AT-RvD1 (100 ng) in saline or a saline vehicle for 24 hours in normoxic (\u224821% O2) conditions after hyperoxia. Lung tissue and bronchoalveolar lavage (BAL) fluid were collected for analysis associated with proinflammatory signaling and lung inflammation. AT-RvD1 treatment resulted in reduced oxidative stress, increased glutathione production, and significantly decreased tissue inflammation. AT-RvD1 treatment also significantly reduced the lung wet\/dry ratio, protein in BAL fluid, and decreased apoptotic and NF-\u03baB signaling. These results show that AT-RvD1 curbs oxygen-induced lung edema, permeability, inflammation, and apoptosis and is thus an effective therapy for prolonged hyperoxia exposure in this murine model.<\/jats:p>","DOI":"10.1165\/rcmb.2014-0339oc","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T16:31:43Z","timestamp":1422981103000},"page":"422-435","source":"Crossref","is-referenced-by-count":72,"title":["Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment"],"prefix":"10.1093","volume":"53","author":[{"suffix":"Jr.","given":"Ruan","family":"Cox","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine and"},{"name":"Molecular Medicine, Division of Allergy and Immunology, Morsani College of Medicine, University of South Florida, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwakemi","family":"Phillips","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutaro","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itsuko","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanna Tamarapu","family":"Parthasarathy","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Arias","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young","family":"Cho","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F.","family":"Lockey","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narasaiah","family":"Kolliputi","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and"},{"name":"Molecular Medicine, Division of Allergy and Immunology, Morsani College of Medicine, University of South Florida, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,9,1]]},"reference":[{"key":"2026021122351807300_bib1","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa050333","article-title":"Incidence and outcomes of acute lung injury","volume":"353","author":"Rubenfeld","year":"2005","journal-title":"N Engl J Med"},{"key":"2026021122351807300_bib2","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1056\/NEJM200005043421806","article-title":"The acute respiratory distress syndrome","volume":"342","author":"Ware","year":"2000","journal-title":"N Engl J Med"},{"key":"2026021122351807300_bib3","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1172\/JCI60331","article-title":"The acute respiratory distress syndrome","volume":"122","author":"Matthay","year":"2012","journal-title":"J Clin Invest"},{"key":"2026021122351807300_bib4","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1146\/annurev.ph.48.030186.003445","article-title":"Morphologic changes in pulmonary oxygen toxicity","volume":"48","author":"Crapo","year":"1986","journal-title":"Annu Rev Physiol"},{"key":"2026021122351807300_bib5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0891-5849(93)90023-N","article-title":"Hyperoxia induces DNA damage in mammalian cells","volume":"14","author":"Cacciuttolo","year":"1993","journal-title":"Free Radic Biol Med"},{"key":"2026021122351807300_bib6","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1165\/ajrcmb.19.4.3173","article-title":"Oxygen toxicity in mouse lung: pathways to cell death","volume":"19","author":"Barazzone","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026021122351807300_bib7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/mgme.2000.3046","article-title":"Signal transduction pathways in hyperoxia-induced lung cell death","volume":"71","author":"Mantell","year":"2000","journal-title":"Mol Genet Metab"},{"key":"2026021122351807300_bib8","doi-asserted-by":"crossref","first-page":"L6","DOI":"10.1152\/ajplung.90381.2008","article-title":"IL-6 cytoprotection in hyperoxic acute lung injury occurs via PI3K\/Akt-mediated Bax phosphorylation","volume":"297","author":"Kolliputi","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026021122351807300_bib9","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1172\/JCI1337","article-title":"Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation","volume":"101","author":"Waxman","year":"1998","journal-title":"J Clin Invest"},{"key":"2026021122351807300_bib10","first-page":"123","article-title":"Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen","volume":"122","author":"Crapo","year":"1980","journal-title":"Am Rev Respir Dis"},{"key":"2026021122351807300_bib11","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.4049\/jimmunol.0902766","article-title":"The inflammasome mediates hyperoxia-induced alveolar cell permeability","volume":"184","author":"Kolliputi","year":"2010","journal-title":"J Immunol"},{"key":"2026021122351807300_bib12","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3109\/01902148.2010.521617","article-title":"Bcl-X(L) is the primary mediator of p21 protection against hyperoxia-induced cell death","volume":"37","author":"Wu","year":"2011","journal-title":"Exp Lung Res"},{"key":"2026021122351807300_bib13","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1165\/rcmb.2008-0302OC","article-title":"IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins","volume":"41","author":"Waxman","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026021122351807300_bib14","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1002\/jcp.24026","article-title":"NALP-3 inflammasome silencing attenuates ceramide-induced transepithelial permeability","volume":"227","author":"Kolliputi","year":"2012","journal-title":"J Cell Physiol"},{"key":"2026021122351807300_bib15","doi-asserted-by":"crossref","first-page":"L604","DOI":"10.1152\/ajplung.00079.2013","article-title":"Protein expression profile of rat type two alveolar epithelial cells during hyperoxic stress and recovery","volume":"305","author":"Bhargava","year":"2013","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026021122351807300_bib16","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ccc.2011.05.013","article-title":"Experimental models and emerging hypotheses for acute lung injury","volume":"27","author":"Martin","year":"2011","journal-title":"Crit Care Clin"},{"key":"2026021122351807300_bib17","doi-asserted-by":"crossref","first-page":"L379","DOI":"10.1152\/ajplung.00010.2008","article-title":"Animal models of acute lung injury","volume":"295","author":"Matute-Bello","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026021122351807300_bib18","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1001\/jama.2011.1435","article-title":"Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury","volume":"306","author":"Rice","year":"2011","journal-title":"JAMA"},{"key":"2026021122351807300_bib19","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1186\/cc8844","article-title":"Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial","volume":"14","author":"Barbosa","year":"2010","journal-title":"Crit Care"},{"key":"2026021122351807300_bib20","doi-asserted-by":"crossref","first-page":"7671","DOI":"10.1073\/pnas.0409271102","article-title":"Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis","volume":"102","author":"Arita","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026021122351807300_bib21","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1084\/jem.20020760","article-title":"Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals","volume":"196","author":"Serhan","year":"2002","journal-title":"J Exp Med"},{"key":"2026021122351807300_bib22","first-page":"1039","article-title":"Resolvin E1 protects against ox-LDL-induced injury on vascular endothelial cells [article in Chinese]","volume":"39","author":"Chen","year":"2011","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"2026021122351807300_bib23","doi-asserted-by":"crossref","first-page":"836","DOI":"10.4049\/jimmunol.0901809","article-title":"The anti-inflammatory and proresolving mediator resolvin E1 protects mice from bacterial pneumonia and acute lung injury","volume":"184","author":"Seki","year":"2010","journal-title":"J Immunol"},{"key":"2026021122351807300_bib24","doi-asserted-by":"crossref","first-page":"496","DOI":"10.4049\/jimmunol.178.1.496","article-title":"Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness","volume":"178","author":"Levy","year":"2007","journal-title":"J Immunol"},{"key":"2026021122351807300_bib25","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1164\/ajrccm\/139.6.1395","article-title":"The effects of dietary supplementation with fish oil lipids on the airways response to inhaled allergen in bronchial asthma","volume":"139","author":"Arm","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"2026021122351807300_bib26","doi-asserted-by":"crossref","first-page":"e58258","DOI":"10.1371\/journal.pone.0058258","article-title":"A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation","volume":"8","author":"Hsiao","year":"2013","journal-title":"PLoS One"},{"key":"2026021122351807300_bib27","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/mi.2012.66","article-title":"Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury","volume":"6","author":"Eickmeier","year":"2013","journal-title":"Mucosal Immunol"},{"key":"2026021122351807300_bib28","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3389\/fimmu.2012.00390","article-title":"Resolvin D1 and resolvin E1 promote the resolution of allergic airway inflammation via shared and distinct molecular counter-regulatory pathways","volume":"3","author":"Levy","year":"2012","journal-title":"Front Immunol"},{"key":"2026021122351807300_bib29","doi-asserted-by":"crossref","first-page":"8S","DOI":"10.1378\/chest.116.suppl_1.8S","article-title":"Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation","volume":"116","author":"Waxman","year":"1999","journal-title":"Chest"},{"key":"2026021122351807300_bib30","doi-asserted-by":"crossref","first-page":"C182","DOI":"10.1152\/ajpcell.00086.2013","article-title":"NLRP3 deletion protects from hyperoxia-induced acute lung injury","volume":"305","author":"Fukumoto","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"key":"2026021122351807300_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1020804916733","article-title":"Antioxidant status during cutaneous wound healing in immunocompromised rats","volume":"241","author":"Gupta","year":"2002","journal-title":"Mol Cell Biochem"},{"key":"2026021122351807300_bib32","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.1365-2613.2000.00158.x","article-title":"Antioxidant status in delayed healing type of wounds","volume":"81","author":"Rasik","year":"2000","journal-title":"Int J Exp Pathol"},{"key":"2026021122351807300_bib33","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.pupt.2012.02.007","article-title":"Selective phosphodiesterase 3 inhibitor olprinone attenuates meconium-induced oxidative lung injury","volume":"25","author":"Mokra","year":"2012","journal-title":"Pulm Pharmacol Ther"},{"key":"2026021122351807300_bib34","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.rmed.2009.04.014","article-title":"Oxidative stress in the pathogenesis of diffuse lung diseases: a review","volume":"103","author":"Bargagli","year":"2009","journal-title":"Respir Med"},{"key":"2026021122351807300_bib35","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/thx.51.4.348","article-title":"Oxidant\/antioxidant imbalance in smokers and chronic obstructive pulmonary disease","volume":"51","author":"Rahman","year":"1996","journal-title":"Thorax"},{"key":"2026021122351807300_bib36","doi-asserted-by":"crossref","first-page":"L267","DOI":"10.1152\/ajplung.00288.2012","article-title":"Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats","volume":"305","author":"Fan","year":"2013","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026021122351807300_bib37","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1164\/ajrccm.163.6.2006131","article-title":"Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1\u03b2-dependent mechanism","volume":"163","author":"Geiser","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"2026021122351807300_bib38","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3109\/01902140902853184","article-title":"Hyperoxia-induced lung injury is dose dependent in Wistar rats","volume":"35","author":"Nagato","year":"2009","journal-title":"Exp Lung Res"},{"key":"2026021122351807300_bib39","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s12519-009-0041-2","article-title":"Melatonin protects against oxidative damage in a neonatal rat model of bronchopulmonary dysplasia","volume":"5","author":"Pan","year":"2009","journal-title":"World J Pediatr"},{"key":"2026021122351807300_bib40","doi-asserted-by":"crossref","first-page":"7264","DOI":"10.4049\/jimmunol.0804248","article-title":"Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice","volume":"182","author":"Reddy","year":"2009","journal-title":"J Immunol"},{"key":"2026021122351807300_bib41","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1042\/bj3030295","article-title":"Interactions of peroxynitrite with human plasma and its constituents: oxidative damage and antioxidant depletion","volume":"303","author":"Van der Vliet","year":"1994","journal-title":"Biochem J"},{"key":"2026021122351807300_bib42","doi-asserted-by":"crossref","first-page":"L246","DOI":"10.1152\/ajplung.00491.2001","article-title":"Antioxidant responses to oxidant-mediated lung diseases","volume":"283","author":"Comhair","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026021122351807300_bib43","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1097\/01.CCM.0000085090.06078.8C","article-title":"Pulmonary edema fluid antioxidants are depressed in acute lung injury","volume":"31","author":"Bowler","year":"2003","journal-title":"Crit Care Med"},{"key":"2026021122351807300_bib44","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.1476-5381.2009.00234.x","article-title":"Resolvin D1 controls inflammation initiated by glutathione-lipid conjugates formed during oxidative stress","volume":"158","author":"Spite","year":"2009","journal-title":"Br J Pharmacol"},{"key":"2026021122351807300_bib45","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/toxsci\/kft071","article-title":"Ozone-induced injury and oxidative stress in bronchiolar epithelium are associated with altered pulmonary mechanics","volume":"133","author":"Sunil","year":"2013","journal-title":"Toxicol Sci"},{"key":"2026021122351807300_bib46","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1089\/ars.2013.5469","article-title":"Lung injury and lung cancer caused by cigarette smoke-induced oxidative stress: molecular mechanisms and therapeutic opportunities involving the ceramide-generating machinery and epidermal growth factor receptor","volume":"21","author":"Goldkorn","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"2026021122351807300_bib47","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1183\/09059180.00010410","article-title":"The role of small airways in obstructive airway diseases","volume":"20","author":"Burgel","year":"2011","journal-title":"Eur Respir Rev"},{"key":"2026021122351807300_bib48","doi-asserted-by":"crossref","first-page":"4785","DOI":"10.4049\/jimmunol.177.7.4785","article-title":"Cyclooxygenase-1 overexpression decreases basal airway responsiveness but not allergic inflammation","volume":"177","author":"Card","year":"2006","journal-title":"J Immunol"},{"key":"2026021122351807300_bib49","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-2466-10-37","article-title":"Associations of airway inflammation and responsiveness markers in non asthmatic subjects at start of apprenticeship","volume":"10","author":"Demange","year":"2010","journal-title":"BMC Pulm Med"},{"key":"2026021122351807300_bib50","doi-asserted-by":"crossref","first-page":"L301","DOI":"10.1152\/ajplung.00082.2013","article-title":"Curcumin protects the developing lung against long-term hyperoxic injury","volume":"305","author":"Sakurai","year":"2013","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026021122351807300_bib51","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1165\/rcmb.2012-0017OC","article-title":"p62 sequestosome 1\/light chain 3b complex confers cytoprotection on lung epithelial cells after hyperoxia","volume":"48","author":"Liang","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026021122351807300_bib52","doi-asserted-by":"crossref","first-page":"L73","DOI":"10.1152\/ajplung.00035.2010","article-title":"Oxidative lipidomics of hyperoxic acute lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation","volume":"299","author":"Tyurina","year":"2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026021122351807300_bib53","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4187\/respcare.01963","article-title":"Hyperoxic acute lung injury","volume":"58","author":"Kallet","year":"2013","journal-title":"Respir Care"},{"key":"2026021122351807300_bib54","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/nm1494","article-title":"Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death","volume":"12","author":"Bhandari","year":"2006","journal-title":"Nat Med"},{"key":"2026021122351807300_bib55","doi-asserted-by":"crossref","first-page":"C999","DOI":"10.1152\/ajpcell.00064.2013","article-title":"Dysregulation of CLOCK gene expression in hyperoxia-induced lung injury","volume":"306","author":"Lagishetty","year":"2014","journal-title":"Am J Physiol Cell Physiol"},{"key":"2026021122351807300_bib56","first-page":"260482","article-title":"Consequences of hyperoxia and the toxicity of oxygen in the lung","volume":"2011","author":"Mach","year":"2011","journal-title":"Nurs Res Pract"},{"key":"2026021122351807300_bib57","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1055\/s-0033-1351163","article-title":"Acute lung injury","volume":"34","author":"Ware","year":"2013","journal-title":"Semin Respir Crit Care Med"},{"key":"2026021122351807300_bib58","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3389\/fphys.2012.00445","article-title":"Putting the brakes on acute lung injury: can resolvins suppress acute lung injury?","volume":"3","author":"Cox","year":"2012","journal-title":"Front Physiol"},{"key":"2026021122351807300_bib59","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fphys.2013.00050","article-title":"TXNIP shuttling: missing link between oxidative stress and inflammasome activation","volume":"4","author":"Lane","year":"2013","journal-title":"Front Physiol"},{"key":"2026021122351807300_bib60","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.4049\/jimmunol.172.6.3860","article-title":"CXCR2 is critical to hyperoxia-induced lung injury","volume":"172","author":"Sue","year":"2004","journal-title":"J Immunol"},{"key":"2026021122351807300_bib61","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1152\/jappl.1978.45.5.699","article-title":"Oxygen toxicity in neonatal and adult animals of various species","volume":"45","author":"Frank","year":"1978","journal-title":"J Appl Physiol"},{"key":"2026021122351807300_bib62","first-page":"1000158","article-title":"Oxidative lung damage resulting from repeated exposure to radiation and hyperoxia associated with space exploration","volume":"3","author":"Pietrofesa","year":"2013","journal-title":"J Pulm Respir Med"},{"key":"2026021122351807300_bib63","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1096\/fj.06-6661com","article-title":"VEGF-induced heme oxygenase-1 confers cytoprotection from lethal hyperoxia in vivo","volume":"21","author":"Siner","year":"2007","journal-title":"FASEB J"},{"key":"2026021122351807300_bib64","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1089\/neu.2004.21.1457","article-title":"Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats","volume":"21","author":"Wu","year":"2004","journal-title":"J Neurotrauma"},{"key":"2026021122351807300_bib65","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/cge.12012","article-title":"Identification of the CFTR p.Phe508Del founder mutation in the absence of a polythymidine 9T allele in a Hispanic patient","volume":"83","author":"Dharajiya","year":"2013","journal-title":"Clin Genet"},{"key":"2026021122351807300_bib66","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jnutbio.2012.05.003","article-title":"Docosahexaenoic acid inhibition of inflammation is partially via cross-talk between Nrf2\/heme oxygenase 1 and IKK\/NF-kappaB pathways","volume":"24","author":"Yang","year":"2013","journal-title":"J Nutr Biochem"},{"key":"2026021122351807300_bib67","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.4049\/jimmunol.173.5.3467","article-title":"Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals","volume":"173","author":"Li","year":"2004","journal-title":"J Immunol"},{"key":"2026021122351807300_bib68","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1136\/thx.2003.012468","article-title":"Acute effects of cigarette smoke on inflammation and oxidative stress: a review","volume":"59","author":"van der Vaart","year":"2004","journal-title":"Thorax"},{"key":"2026021122351807300_bib69","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1172\/JCI105506","article-title":"Lung tissue resistance in diffuse interstitial pulmonary fibrosis","volume":"46","author":"Bachofen","year":"1967","journal-title":"J Clin Invest"},{"key":"2026021122351807300_bib70","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1084\/jem.20132413","article-title":"Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF","volume":"211","author":"Finsterbusch","year":"2014","journal-title":"J Exp Med"},{"key":"2026021122351807300_bib71","doi-asserted-by":"crossref","first-page":"L152","DOI":"10.1152\/ajplung.00229.2013","article-title":"Extracellular ATP mediates the late phase of neutrophil recruitment to the lung in murine models of acute lung injury","volume":"306","author":"Shah","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026021122351807300_bib72","doi-asserted-by":"crossref","first-page":"e79037","DOI":"10.1371\/journal.pone.0079037","article-title":"Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-alpha antibodies","volume":"8","author":"Bhargava","year":"2013","journal-title":"PLoS One"},{"key":"2026021122351807300_bib73","doi-asserted-by":"crossref","first-page":"848","DOI":"10.4049\/jimmunol.1202941","article-title":"Neutrophil recruitment to the lung in both C5a- and CXCL1-induced alveolitis is impaired in vitamin D-binding protein-deficient mice","volume":"191","author":"Trujillo","year":"2013","journal-title":"J Immunol"},{"key":"2026021122351807300_bib74","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3109\/08958378.2012.750405","article-title":"Docosahexaenoic acid (DHA) attenuated paraquat induced lung damage in mice","volume":"25","author":"Chen","year":"2013","journal-title":"Inhal Toxicol"},{"key":"2026021122351807300_bib75","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.pupt.2012.05.009","article-title":"Dexamethasone down-regulates the inflammatory mediators but fails to reduce the tissue injury in the lung of acute pancreatitis rat models","volume":"25","author":"Yubero","year":"2012","journal-title":"Pulm Pharmacol Ther"},{"key":"2026021122351807300_bib76","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.4187\/respcare.00770","article-title":"Long-term simvastatin attenuates lung injury and oxidative stress in murine acute lung injury models induced by oleic acid and endotoxin","volume":"56","author":"Altintas","year":"2011","journal-title":"Respir Care"},{"key":"2026021122351807300_bib77","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.intimp.2011.01.011","article-title":"Isoforskolin pretreatment attenuates lipopolysaccharide-induced acute lung injury in animal models","volume":"11","author":"Yang","year":"2011","journal-title":"Int Immunopharmacol"},{"key":"2026021122351807300_bib78","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1172\/JCI119089","article-title":"Plasminogen activator inhibitor-1 in acute hyperoxic mouse lung injury","volume":"98","author":"Barazzone","year":"1996","journal-title":"J Clin Invest"},{"key":"2026021122351807300_bib79","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1097\/ALN.0b013e3182518bc0","article-title":"Ventilator-induced lung injury is mediated by the NLRP3 inflammasome","volume":"116","author":"Kuipers","year":"2012","journal-title":"Anesthesiology"},{"key":"2026021122351807300_bib80","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1164\/rccm.201201-0003OC","article-title":"Inflammasome-regulated cytokines are critical mediators of acute lung injury","volume":"185","author":"Dolinay","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"2026021122351807300_bib81","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1161\/CIRCRESAHA.107.161067","article-title":"Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms","volume":"102","author":"Ganter","year":"2008","journal-title":"Circ Res"},{"key":"2026021122351807300_bib82","doi-asserted-by":"crossref","first-page":"e63907","DOI":"10.1371\/journal.pone.0063907","article-title":"HMGB1 accelerates alveolar epithelial repair via an IL-1beta- and alphavbeta6 integrin-dependent activation of TGF-beta1","volume":"8","author":"Pittet","year":"2013","journal-title":"PLoS One"},{"key":"2026021122351807300_bib83","doi-asserted-by":"crossref","first-page":"L227","DOI":"10.1152\/ajplung.00224.2004","article-title":"Involvement of p42\/p44 MAPK, p38 MAPK, JNK, and NF-kappaB in IL-1beta-induced VCAM-1 expression in human tracheal smooth muscle cells","volume":"288","author":"Wang","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026021122351807300_bib84","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/jcp.20142","article-title":"Involvement of p42\/p44 MAPK, JNK, and NF-kappaB in IL-1beta-induced ICAM-1 expression in human pulmonary epithelial cells","volume":"202","author":"Lin","year":"2005","journal-title":"J Cell Physiol"},{"key":"2026021122351807300_bib85","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.4049\/jimmunol.162.9.5367","article-title":"The role of p38 mitogen-activated protein kinase in IL-1 beta transcription","volume":"162","author":"Baldassare","year":"1999","journal-title":"J Immunol"},{"key":"2026021122351807300_bib86","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1096\/fasebj.13.10.1137","article-title":"Karin M. Is NF-\u03baB the sensor of oxidative stress?","volume":"13","author":"Li N","year":"1999","journal-title":"FASEB J"},{"key":"2026021122351807300_bib87","first-page":"419","article-title":"Epithelial cell apoptosis and lung remodeling","volume":"4","author":"Kuwano","year":"2007","journal-title":"Cell Mol Immunol"},{"key":"2026021122351807300_bib88","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1165\/ajrcmb.18.1.2950m","article-title":"Exposure to hyperoxia induces p53 expression in mouse lung epithelium","volume":"18","author":"O'Reilly","year":"1998","journal-title":"Am J Respir Cell Mol Biol"}],"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/53\/3\/422\/66832915\/ajrcmb_53_3_422.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/53\/3\/422\/66832915\/ajrcmb_53_3_422.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T03:38:17Z","timestamp":1770867497000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/53\/3\/422\/8467957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,1]]},"references-count":88,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,9,1]]},"published-print":{"date-parts":[[2015,9,1]]}},"URL":"https:\/\/doi.org\/10.1165\/rcmb.2014-0339oc","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,9]]},"published":{"date-parts":[[2015,9,1]]}}}