{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:15:47Z","timestamp":1781763347800,"version":"3.54.5"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Asthma is a heterogeneous disease characterized by airway inflammation and hyperreactivity. IL-17 receptor A (IL-17RA) is a shared receptor subunit required for activity of IL-17 family cytokines, including IL-17A and IL-25. IL-17A and IL-25 induce different proinflammatory responses, and concentrations are elevated in subjects with asthma. However, the individual contributions of IL-17A and IL-25 to disease pathogenesis are unclear. We explored proinflammatory activities of the IL-17 pathway in models of pulmonary inflammation and assessed its effects on contractility of human bronchial airway smooth muscle. In two mouse models, IL-17RA, IL-17RB, or IL-25 blockade reduced airway inflammation and airway hyperreactivity. Individually, IL-17A and IL-25 enhanced contractility of human bronchial smooth muscle induced by methacholine or carbachol. IL-17A had more pronounced effects on methacholine-induced contractility in bronchial rings from donors with asthma compared with donors without asthma. Blocking the IL-17 pathway via IL-17RA may be a useful therapy for some patients with asthma by reducing pulmonary inflammation and airway hyperreactivity.<\/jats:p>","DOI":"10.1165\/rcmb.2015-0038oc","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T15:10:41Z","timestamp":1430233841000},"page":"810-821","source":"Crossref","is-referenced-by-count":64,"title":["IL-17RA Signaling in Airway Inflammation and Bronchial Hyperreactivity in Allergic Asthma"],"prefix":"10.1093","volume":"53","author":[{"given":"Cynthia R.","family":"Willis","sequence":"first","affiliation":[{"name":"Inflammation Research, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Siegel","sequence":"additional","affiliation":[{"name":"Inflammation Research, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh","family":"Leith","sequence":"additional","affiliation":[{"name":"Inflammation Research, 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