{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:53:02Z","timestamp":1789977182337,"version":"4.0.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report that S100 proteins were reduced in patients with chronic rhinosinusitis (CRS). S100A8\/9, which is important in epithelial barrier function, was particularly decreased in elderly patients with CRS. Epithelial expression of S100A8\/9 is partly regulated by the IL-6 trans-signaling pathway. The goal of this study was to investigate whether or not age-related reduction of S100A8\/9 in CRS is associated with blunting of IL-6 trans-signaling. The levels of IL-6, soluble IL-6 receptor (sIL-6R), soluble gp130 (sgp130), and S100A8\/9 from control subjects (n\u2009=\u200910), and patients with CRS without nasal polyps (n\u2009=\u200913) and those with CRS with nasal polyps (CRSwNP) (n\u2009=\u200914), were measured by ELISA. Age-related differences in the level of each protein were investigated. Normal human bronchial epithelial cells were cultured in air\u2013liquid interface and stimulated with IL-6\/sIL-6R and tumor necrosis factor (TNF)-\u03b1 with or without the addition of sgp130, a natural inhibitor of IL-6 trans-signaling. There was a significant age-related decline in S100A8\/9 and an increase in sgp130 in nasal tissue samples from patients with CRSwNP, although there was no age-related difference in IL-6\/sIL-6R production. Additionally, expression of the S100A8\/9 gene and protein was increased significantly by IL-6\/sIL-6R plus TNF-\u03b1 in normal human bronchial epithelial cells. This increase was blocked by sgp130. These results suggest that increased sgp130 in older patients may inhibit IL-6 trans-signaling, impair barrier function, and decrease S1008\/9 production in elderly patients with CRSwNP. Restoration of barrier function by targeting sgp130 may be a novel treatment strategy.<\/jats:p>","DOI":"10.1165\/rcmb.2015-0207rc","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T16:42:56Z","timestamp":1439397776000},"page":"601-606","source":"Crossref","is-referenced-by-count":50,"title":["Age-Related Increased Prevalence of Asthma and Nasal Polyps in Chronic Rhinosinusitis and Its Association with Altered IL-6 Trans-Signaling"],"prefix":"10.1093","volume":"53","author":[{"given":"Seong H.","family":"Cho","sequence":"first","affiliation":[{"name":"Division of Allergy-Immunology, Department of Medicine, and"},{"name":"Division of Allergy-Immunology, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida"},{"name":"Division of Rheumatology, Department of Medicine, Kyung Hee University School of Medicine, Seoul, Korea; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae 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