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In this study, we demonstrate that mice with CARMA3-deficient AECs have reduced airway inflammation, as well as reduced type 2 cytokine levels in response to Alternaria alternata. These mice also have reduced production of IL-33 and IL-25, and reduced numbers of innate lymphoid cells in the lung. We also show that CARMA3-deficient human AECs have decreased production of proasthmatic mediators in response to A. alternata. Finally, we show that CARMA3 interacts with inositol 1,4,5-trisphosphate receptors in AECs, and that inhibition of CARMA3 signaling reduces A. alternata\u2013induced intracellular calcium release. In conclusion, we show that CARMA3 signaling in AECs helps mediate A. alternata\u2013induced allergic airway inflammation, and that CARMA3 is an important signaling molecule for type 2 immune responses in the lung.<\/jats:p>","DOI":"10.1165\/rcmb.2017-0181oc","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T13:28:27Z","timestamp":1530278907000},"page":"684-694","source":"Crossref","is-referenced-by-count":19,"title":["CARMA3 Mediates Allergic Lung Inflammation in Response to\n                    <i>Alternaria alternata<\/i>"],"prefix":"10.1093","volume":"59","author":[{"given":"Benjamin","family":"Causton","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine"},{"name":"Center for Regenerative Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Pardo-Saganta","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine"},{"name":"Center 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