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To better understand the duality of IL-8\u2013dependent host immunity to bacterial infection and lung pathology, we expressed human IL-8 transgenically in murine bronchial epithelium, and investigated the impact of overexpression on lung bacterial clearance, host immunity, and lung pathology and function. Persistent IL-8 expression in bronchial epithelium resulted in neutrophilia, neutrophil maturation and activation, and chemotaxis. There was enhanced protection against challenge with Pseudomonas aeruginosa, and significant changes in baseline expression of innate and adaptive immunity transcripts for Ccl5, Tlr6, IL-2, and Tlr1. There was increased expression of Tbet and Foxp3 in response to the Pseudomonas antigen OprF, indicating a regulatory T-cell phenotype. However, this enhanced bacterial immunity came at a high price of progressive lung remodeling, with increased inflammation, mucus hypersecretion, and fibrosis. There was increased expression of Ccl3 and reduced expression of Claudin 18 and F11r, with damage to epithelial organization leading to leaky tight junctions, all of which resulted in impaired lung function with reduced compliance, increased resistance, and bronchial hyperreactivity as measured by whole-body plethysmography. These results show that IL-8 overexpression in the bronchial epithelium benefits lung immunity to bacterial infection, but specifically drives lung damage through persistent inflammation, lung remodeling, and damaged tight junctions, leading to impaired lung function.<\/jats:p>","DOI":"10.1165\/rcmb.2018-0007oc","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T14:59:12Z","timestamp":1528815552000},"page":"557-571","source":"Crossref","is-referenced-by-count":64,"title":["Lung Defense through IL-8 Carries a Cost of Chronic Lung Remodeling and Impaired Function"],"prefix":"10.1093","volume":"59","author":[{"given":"Catherine J.","family":"Reynolds","sequence":"first","affiliation":[{"name":"Lung Immunology Group, Infectious Disease and Immunity, Department of Medicine, Imperial College London, London, United Kingdom"},{"name":"MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom; 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