{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:22:42Z","timestamp":1787318562172,"version":"build-2736575974"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>No previously suggested biomarkers of nasal mucosal inflammation have been practically applied in clinical fields, and nasal epithelium\u2013derived secreted proteins as biomarkers have not specifically been investigated. The goal of this study was to identify secreted proteins that dynamically change during the differentiation from basal cells to fully differentiated cells and examine whether nasal epithelium\u2013derived proteins can be used as biomarkers of nasal mucosal inflammation, such as chronic rhinosinusitis. To achieve this goal, we analyzed two secretomes using the isobaric tag for relative and absolute quantification technique. From in vitro secretomes, we identified the proteins altered in apical secretions of primary human nasal epithelial cells according to the degree of differentiation; from in vivo secretomes, we identified the increased proteins in nasal lavage fluids obtained from patients 2 weeks after endoscopic sinus surgery for chronic sinusitis. We then used a parallel approach to identify specific biomarkers of nasal mucosal inflammation; first, we selected apolipoprotein E as a nasal epithelial cell\u2013derived biomarker through screening proteins that were upregulated in both in vitro and in vivo secretomes, and verified highly secreted apolipoprotein E in nasal lavage fluids of the patients by Western blotting. Next, we selected periostin as an inflammatory mediator\u2013inducible biomarker from in vivo secretomes, the secretion of which was not induced under in vitro culture conditions. We demonstrated that those two nasal epithelium\u2013derived proteins are possible biomarkers of nasal mucosal inflammation.<\/jats:p>","DOI":"10.1165\/rcmb.2018-0248oc","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T19:06:10Z","timestamp":1560452770000},"page":"23-34","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":18,"title":["Apolipoprotein E and Periostin Are Potential Biomarkers of Nasal Mucosal Inflammation. A Parallel Approach of\n                    <i>In Vitro<\/i>\n                    and\n                    <i>In Vivo<\/i>\n                    Secretomes"],"prefix":"10.1093","volume":"62","author":[{"given":"Youn Wook","family":"Chung","sequence":"first","affiliation":[{"name":"The Airway Mucus Institute"},{"name":"Global Research Laboratory for Allergic Airway Disease"},{"name":"Severance Biomedical Science Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Cha","sequence":"additional","affiliation":[{"name":"Severance Biomedical Science Institute"},{"name":"Brain Korea 21 PLUS Project for Medical Science, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghan","family":"Han","sequence":"additional","affiliation":[{"name":"Severance Biomedical Science Institute"},{"name":"Brain Korea 21 PLUS Project for Medical Science, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"Proteomics Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Gucek","sequence":"additional","affiliation":[{"name":"Proteomics Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-Ju","family":"Cho","sequence":"additional","affiliation":[{"name":"The Airway Mucus Institute"},{"name":"Global Research Laboratory for Allergic Airway Disease"},{"name":"Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiichi","family":"Nakahira","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustine M. K.","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. 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