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We hypothesized that hyperoxia, a factor contributing to the development of bronchopulmonary dysplasia, perturbs human lung\u2013resident MSC function. Mesenchymal cells were isolated from human fetal lung tissue (16\u201318 wk of gestation), characterized and cultured in conditions resembling either intrauterine (5% O2) or extrauterine (21% and 60% O2) atmospheres. Secretome data were compared with MSCs obtained from term umbilical cord tissues. The human fetal lung mesenchyme almost exclusively contains CD146pos. MSCs expressing SOX-2 and OCT-4, which secrete elastin, fibroblast growth factors 7 and 10, vascular endothelial growth factor, angiogenin, and other lung cell\u2013protecting\/\u2013maturing proteins. Exposure to extrauterine atmospheres in vitro leads to excessive proliferation, reduced colony-forming ability, alterations in the cell\u2019s surface marker profile, decreased elastin deposition, and impaired secretion of factors important for lung growth. Conversely, umbilical cord\u2013derived MSCs abundantly secreted factors that impaired lung MSCs are unable to produce. Oxygen-impaired human fetal lung MSC function may contribute to disrupted repair capacity and arrested lung growth. Exogenous MSCs may act by triggering the signaling pathways lost by impaired endogenous lung mesenchymal cells.<\/jats:p>","DOI":"10.1165\/rcmb.2018-0358oc","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T13:25:00Z","timestamp":1545139500000},"page":"592-600","source":"Crossref","is-referenced-by-count":34,"title":["Oxygen Disrupts Human Fetal Lung Mesenchymal Cells. Implications for Bronchopulmonary Dysplasia"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8811-8454","authenticated-orcid":false,"given":"Marius A.","family":"M\u00f6bius","sequence":"first","affiliation":[{"name":"Fachbereich Neonatologie und P\u00e4diatrische Intensivmedizin, Klinik und Poliklinik f\u00fcr Kinder- und Jugendmedizin, Universit\u00e4tsklinikum und Medizinische Fakult\u00e4t Carl Gustav Carus der Technischen Universit\u00e4t Dresden, Dresden, Saxony, Germany"},{"name":"Deutsche Forschungsgemeinschaft Research Center and Cluster of Excellence for Regenerative Therapies Dresden, Technische Universit\u00e4t Dresden, Dresden, Saxony, Germany"},{"name":"Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Freund","sequence":"additional","affiliation":[{"name":"Fachbereich Neonatologie und P\u00e4diatrische Intensivmedizin, Klinik und Poliklinik f\u00fcr Kinder- und Jugendmedizin, Universit\u00e4tsklinikum und Medizinische Fakult\u00e4t Carl Gustav Carus der Technischen Universit\u00e4t Dresden, Dresden, Saxony, Germany"},{"name":"Deutsche Forschungsgemeinschaft Research Center and Cluster of Excellence for Regenerative Therapies Dresden, Technische Universit\u00e4t Dresden, Dresden, Saxony, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arul","family":"Vadivel","sequence":"additional","affiliation":[{"name":"Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Koss","sequence":"additional","affiliation":[{"name":"Fachbereich Neonatologie und P\u00e4diatrische Intensivmedizin, Klinik und Poliklinik f\u00fcr Kinder- und Jugendmedizin, Universit\u00e4tsklinikum und Medizinische Fakult\u00e4t Carl Gustav Carus der 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