{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:25:24Z","timestamp":1770816324866,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The development of regional lung injury in the preterm lung is not well understood. This study aimed to characterize time-dependent and regionally specific injury patterns associated with early ventilation of the preterm lung using a mass spectrometry\u2013based proteomic approach. Preterm lambs delivered at 124\u2013127 days gestation received 15 or 90 minutes of mechanical ventilation (positive end-expiratory pressure\u2009=\u20098 cm H2O, Vt\u2009=\u20096\u20138 ml\/kg) and were compared with unventilated control lambs. At study completion, lung tissue was taken from standardized nondependent and dependent regions, and assessed for lung injury via histology, quantitative PCR, and proteomic analysis using Orbitrap\u2013mass spectrometry. Ingenuity pathway analysis software was used to identify temporal and region-specific enrichments in pathways and functions. Apoptotic cell numbers were ninefold higher in nondependent lung at 15 and 90 minutes compared with controls, whereas proliferative cells were increased fourfold in the dependent lung at 90 minutes. The relative gene expression of lung injury markers was increased at 90 minutes in nondependent lung and unchanged in gravity-dependent lung. Within the proteome, the number of differentially expressed proteins was fourfold higher in the nondependent lung than the dependent lung. The number of differential proteins increased over time in both lung regions. A total of 95% of enriched canonical pathways and 94% of enriched cellular and molecular functions were identified only in nondependent lung tissue from the 90-minute ventilation group. In conclusion, complex injury pathways are initiated within the preterm lung after 15 minutes of ventilation and amplified by continuing ventilation. Injury development is region specific, with greater alterations within the proteome of nondependent lung.<\/jats:p>","DOI":"10.1165\/rcmb.2019-0084oc","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T14:28:27Z","timestamp":1555511307000},"page":"631-642","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":24,"title":["Preterm Lung Exhibits Distinct Spatiotemporal Proteome Expression at Initiation of Lung Injury"],"prefix":"10.1093","volume":"61","author":[{"given":"Prue M.","family":"Pereira-Fantini","sequence":"first","affiliation":[{"name":"Neonatal Research, and"},{"name":"Department of Paediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyuan","family":"Pang","sequence":"additional","affiliation":[{"name":"Neonatal Research, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean 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