{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:54:10Z","timestamp":1789764850967,"version":"4.0.1"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic airway inflammation from recurring exposures to noxious environmental stimuli results in a progressive and irreversible airflow limitation and the lung parenchymal damage that characterizes chronic obstructive pulmonary disease (COPD). The large variability observed in the onset and progression of COPD is primarily driven by complex gene\u2013environment interactions. The transcriptomic and epigenetic memory potential of lung epithelial and innate immune cells drive responses, such as mucus hyperreactivity and airway remodeling, that are tightly regulated by various molecular mechanisms, for which several candidate susceptibility genes have been described. However, the recently described noncoding RNA species, in particular the long noncoding RNAs, may also have an important role in modulating pulmonary responses to chronic inhalation of toxic substances and the development of COPD. This review outlines the features of long noncoding RNAs that have been implicated in regulating the airway inflammatory responses to cigarette smoke exposure and their possible association with COPD pathogenesis. As COPD continues to debilitate the increasingly aging population and contribute to higher morbidity and mortality rates worldwide, the search for better biomarkers and alternative therapeutic options is pivotal.<\/jats:p>","DOI":"10.1165\/rcmb.2019-0184tr","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T10:05:13Z","timestamp":1567677913000},"page":"678-688","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":58,"title":["Long Noncoding Transcriptome in Chronic Obstructive Pulmonary Disease"],"prefix":"10.1093","volume":"61","author":[{"given":"Dinesh","family":"Devadoss","sequence":"first","affiliation":[{"name":"Department of Immunology and Nano-Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Immunology and Nano-Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond J.","family":"Langley","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of South Alabama, Mobile, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Manevski","sequence":"additional","affiliation":[{"name":"Department of Immunology and Nano-Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhavan","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Immunology and Nano-Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Campos","sequence":"additional","affiliation":[{"name":"Pulmonary Section, Miami Veterans Administration Medical Center, Miami, Florida"},{"name":"Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Miller School of Medicine, University of Miami, Coral Gables, Florida; 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