{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:24:54Z","timestamp":1770834294313,"version":"3.50.1"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Asthma is a common respiratory disease currently affecting more than 300 million worldwide and is characterized by airway inflammation, hyperreactivity, and remodeling. It is a heterogeneous disease consisting of corticosteroid-sensitive T-helper cell type 2\u2013driven eosinophilic and corticosteroid-resistant, T-helper cell type 17-driven neutrophilic phenotypes. One pathway recently described to regulate asthma pathogenesis is cholesterol trafficking. Scavenger receptors, in particular SR-BI (scavenger receptor class B type I), are known to direct cellular cholesterol uptake and efflux. We recently defined SR-BI functions in pulmonary host defense; however, the function of SR-BI in asthma pathogenesis is unknown. To elucidate the role of SR-BI in allergic asthma, SR-BI\u2013sufficient (SR-BI+\/+) and SR-BI\u2013deficient (SR-BI\u2212\/\u2212) mice were sensitized (Days 0 and 7) and then challenged (Days 14, 15, and 16) with a house dust mite (HDM) preparation administered through oropharyngeal aspiration. Airway inflammation and cytokine production were quantified on Day 17. When compared with SR-BI+\/+ mice, the HDM-challenged SR-BI\u2212\/\u2212 mice had increased neutrophils and pulmonary IL-17A production in BAL fluid. This augmented IL-17A production in SR-BI\u2212\/\u2212 mice originated from a non\u2013T-cell source that included neutrophils and alveolar macrophages. Given that SR-BI regulates adrenal steroid hormone production, we tested whether the changes in SR-BI\u2212\/\u2212 mice were glucocorticoid dependent. Indeed, SR-BI\u2212\/\u2212 mice were adrenally insufficient during the HDM challenge, and corticosterone replacement decreased pulmonary neutrophilia and IL-17A production in SR-BI\u2212\/\u2212 mice. Taken together, these data indicate that SR-BI dampens pulmonary neutrophilic inflammation and IL-17A production in allergic asthma at least in part by maintaining adrenal function.<\/jats:p>","DOI":"10.1165\/rcmb.2020-0007oc","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T19:22:17Z","timestamp":1614626537000},"page":"698-708","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":13,"title":["Scavenger Receptor BI Attenuates IL-17A\u2013Dependent Neutrophilic Inflammation in Asthma"],"prefix":"10.1093","volume":"64","author":[{"given":"Sky W.","family":"Reece","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Varikuti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The Ohio State University Wexner Medical Center, The Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brita","family":"Kilburg-Basnyat","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katelyn","family":"Dunigan-Russell","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The Ohio State University Wexner Medical Center, The Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myles X.","family":"Hodge","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer H.","family":"Madenspacher","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seddon Y.","family":"Thomas","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra A.","family":"Tokarz","sequence":"additional","affiliation":[{"name":"Center for Human Health and the Environment, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3465-9861","authenticated-orcid":false,"given":"Robert M.","family":"Tighe","sequence":"additional","affiliation":[{"name":"Department of Medicine, Duke University, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald N.","family":"Cook","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Fessler","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7227-0697","authenticated-orcid":false,"given":"Kymberly M.","family":"Gowdy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina"},{"name":"Department of Internal Medicine, The Ohio State University Wexner Medical Center, The Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"2026021100461138200_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-4614-8603-9_2","article-title":"Epidemiology of asthma: prevalence and burden of disease","volume":"795","author":"Croisant","year":"2014","journal-title":"Adv Exp Med 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