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In the lung, airway macrophages are critical for maintaining the functionality of airways via the clearance of inhaled particles, cell debris, and infectious agents. Exposure of these cells to pathogenic organisms or particles can induce a variety of RCD pathways that promote the release of danger signals into the lung. These responses have evolved to trigger the innate and adaptive arms of the immune system and thus offer protection against pathogens; yet they can also contribute to the development of lung injury and pathogenic immune responses. In this review, we discuss recent studies that suggest a critical role for airway-macrophage RCD pathways in promoting the release of pulmonary danger signals in health and disease.<\/jats:p>","DOI":"10.1165\/rcmb.2020-0420tr","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T19:26:09Z","timestamp":1608233169000},"page":"547-556","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":34,"title":["Pulmonary Macrophage Cell Death in Lung Health and Disease"],"prefix":"10.1093","volume":"64","author":[{"given":"Abigail M.","family":"Shotland","sequence":"first","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Fontenot","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of Medicine, and"},{"name":"Department of 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