{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T01:35:52Z","timestamp":1769132152072,"version":"3.49.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":1574,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Excessive lung inflammation and airway epithelial damage are hallmarks of human inflammatory lung diseases, such as cystic fibrosis (CF). Enhancement of innate immunity provides protection against pathogens while reducing lung-damaging inflammation. However, the mechanisms underlying innate immunity\u2013mediated protection in the lung remain mysterious, in part because of the lack of appropriate animal models for these human diseases. TLR5 (Toll-like receptor 5) stimulation by its specific ligand, the bacterial protein flagellin, has been proposed to enhance protection against several respiratory infectious diseases, although other cellular events, such as calcium signaling, may also control the intensity of the innate immune response. Here, we investigated the molecular events prompted by stimulation with flagellin and its role in regulating innate immunity in the lung of the pig, which is anatomically and genetically more similar to humans than rodent models. We found that flagellin treatment modulated NF-\u03baB signaling and intracellular calcium homeostasis in airway epithelial cells. Flagellin pretreatment reduced the NF-\u03baB nuclear translocation and the expression of proinflammatory cytokines to a second flagellin stimulus as well as to Pseudomonas aeruginosa infection. Moreover, in vivo administration of flagellin decreased the severity of P. aeruginosa\u2013induced pneumonia. Then we confirmed these beneficial effects of flagellin in a pathological model of CF by using ex vivo precision-cut lung slices from a CF pigz model. These results provide evidence that flagellin treatment contributes to a better regulation of the inflammatory response in inflammatory lung diseases such as CF.<\/jats:p>","DOI":"10.1165\/rcmb.2021-0125oc","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T18:24:37Z","timestamp":1623176677000},"page":"378-389","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":20,"title":["Airway Administration of Flagellin Regulates the Inflammatory Response to\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1093","volume":"65","author":[{"given":"Raquel","family":"L\u00f3pez-G\u00e1lvez","sequence":"first","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 1282: Infectiologie et Sant\u00e9 Publique, Centre de Recherche Val de Loire, Universit\u00e9 de Tours\u2013Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Nouzilly, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Fleurot","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 1282: Infectiologie et Sant\u00e9 Publique, Centre de Recherche Val de Loire, Universit\u00e9 de Tours\u2013Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Nouzilly, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Chamero","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 0085: Laboratoire de Physiologie de la Reproduction et des Comportements, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement\u2013Centre National de la Recherche Scientifique\u2013Institut Fran\u00e7ais du Cheval et de l\u2019\u00c9quitation\u2013Universit\u00e9 de Tours, Nouzilly, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sascha","family":"Trapp","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 1282: Infectiologie et Sant\u00e9 Publique, Centre de Recherche Val de Loire, Universit\u00e9 de Tours\u2013Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Nouzilly, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Olivier","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 1282: Infectiologie et Sant\u00e9 Publique, Centre de Recherche Val de Loire, Universit\u00e9 de Tours\u2013Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Nouzilly, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Chevaleyre","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 1282: Infectiologie et Sant\u00e9 Publique, Centre de 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