{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T01:34:03Z","timestamp":1769132043376,"version":"3.49.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":1270,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Dutch Cardiovascular Research Alliance","award":["PHAEDRA-IMACT consortium grant"],"award-info":[{"award-number":["PHAEDRA-IMACT consortium grant"]}]},{"name":"Dutch Cardiovascular Research Alliance","award":["PHAEDRA-IMACT consortium grant"],"award-info":[{"award-number":["PHAEDRA-IMACT consortium grant"]}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"DOI":"10.1165\/rcmb.2022-0122ed","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T13:55:56Z","timestamp":1652795756000},"page":"147-149","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":0,"title":["Tyrosine Kinases and Endothelial Homeostasis in Pulmonary Arterial Hypertension: Too Hot to Handle?"],"prefix":"10.1093","volume":"67","author":[{"given":"Harm Jan","family":"Bogaard","sequence":"first","affiliation":[{"name":"Pulmonary Diseases Amsterdam UMC, Locatie VUMC Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurjan","family":"Aman","sequence":"additional","affiliation":[{"name":"Pulmonary Diseases Amsterdam UMC, Locatie VUMC Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"key":"2026012203593117500_bib1","doi-asserted-by":"crossref","first-page":"1801887","DOI":"10.1183\/13993003.01887-2018","article-title":"Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives","volume":"53","author":"Humbert","year":"2019","journal-title":"Eur Respir J"},{"key":"2026012203593117500_bib2","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1183\/09031936.00046612","article-title":"Pathobiology of pulmonary arterial hypertension and right ventricular failure","volume":"40","author":"Voelkel","year":"2012","journal-title":"Eur Respir J"},{"key":"2026012203593117500_bib3","doi-asserted-by":"crossref","first-page":"L1115","DOI":"10.1152\/ajplung.00476.2019","article-title":"The hallmarks of severe pulmonary arterial hypertension: the cancer hypothesis-ten years later","volume":"318","author":"Cool","year":"2020","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026012203593117500_bib4","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.chest.2021.10.010","article-title":"Novel mechanisms targeted by drug trials in pulmonary arterial hypertension","volume":"161","author":"Condon","year":"2022","journal-title":"Chest"},{"key":"2026012203593117500_bib5","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1172\/JCI86249","article-title":"Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension","volume":"126","author":"Guignabert","year":"2016","journal-title":"J Clin Invest"},{"key":"2026012203593117500_bib6","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/MCP.0000000000000412","article-title":"Pulmonary arterial hypertension induced by tyrosine kinase inhibitors","volume":"23","author":"Weatherald","year":"2017","journal-title":"Curr Opin Pulm Med"},{"key":"2026012203593117500_bib7","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1172\/JCI24838","article-title":"Reversal of experimental pulmonary hypertension by PDGF inhibition","volume":"115","author":"Schermuly","year":"2005","journal-title":"J Clin Invest"},{"key":"2026012203593117500_bib8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1165\/rcmb.2021-0332OC","article-title":"Loss of cAbl tyrosine kinase in pulmonary arterial hypertension causes dysfunction of vascular endothelial cells","volume":"67","author":"Le Vely","year":"2022","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012203593117500_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1242\/jcs.175521","article-title":"Multifunctional Abl kinases in health and disease","volume":"129","author":"Khatri","year":"2016","journal-title":"J Cell Sci"},{"key":"2026012203593117500_bib10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-0-387-69116-9_15","article-title":"Regulation for nuclear targeting of the Abl tyrosine kinase in response to DNA damage","volume":"604","author":"Yoshida","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"2026012203593117500_bib11","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1165\/rcmb.2011-0296OC","article-title":"Copper dependence of angioproliferation in pulmonary arterial hypertension in rats and humans","volume":"46","author":"Bogaard","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012203593117500_bib12","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1164\/rccm.201506-1231OC","article-title":"Delayed microvascular shear adaptation in pulmonary arterial hypertension. Role of platelet endothelial cell adhesion molecule-1 cleavage","volume":"193","author":"Szulcek","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012203593117500_bib13","doi-asserted-by":"crossref","first-page":"eaaw4974","DOI":"10.1126\/scitranslmed.aaw4974","article-title":"Cellular senescence impairs the reversibility of pulmonary arterial hypertension","volume":"12","author":"van der Feen","year":"2020","journal-title":"Sci Transl Med"},{"key":"2026012203593117500_bib14","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1161\/CIRCRESAHA.109.201673","article-title":"Phosphorylation of caveolin-1 regulates oxidant-induced pulmonary vascular permeability via paracellular and transcellular pathways","volume":"105","author":"Sun","year":"2009","journal-title":"Circ Res"},{"key":"2026012203593117500_bib15","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1182\/blood-2009-05-223776","article-title":"c-Abl mediates endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 and by disruption of actin","volume":"115","author":"Xu","year":"2010","journal-title":"Blood"},{"key":"2026012203593117500_bib16","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI122440","article-title":"c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow","volume":"129","author":"Li","year":"2019","journal-title":"J Clin Invest"},{"key":"2026012203593117500_bib17","doi-asserted-by":"crossref","first-page":"re6","DOI":"10.1126\/scisignal.3139re6","article-title":"ABL tyrosine kinases: evolution of function, regulation, and specificity","volume":"3","author":"Colicelli","year":"2010","journal-title":"Sci Signal"},{"key":"2026012203593117500_bib18","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3892\/etm.2022.11111","article-title":"CBL knockdown protects cardiomyocytes against hypoxia-reoxygenation injury by downregulating GRB2 expression","volume":"23","author":"Lv","year":"2022","journal-title":"Exp Ther Med"},{"key":"2026012203593117500_bib19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/mds.28907","article-title":"c-Abl inhibitors as disease-modifying therapies for Parkinson\u2019s disease: gaps and opportunities","volume":"37","author":"Merchant","year":"2022","journal-title":"Mov Disord"},{"key":"2026012203593117500_bib20","doi-asserted-by":"crossref","DOI":"10.1177\/20458940211052823","article-title":"Positioning imatinib for pulmonary arterial hypertension: a phase I\/II design comprising dose finding and single-arm efficacy","volume":"11","author":"Wilkins","year":"2021","journal-title":"Pulm Circ"}],"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/67\/2\/147\/66464202\/ajrcmb_67_2_147.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/67\/2\/147\/66464202\/ajrcmb_67_2_147.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:04:32Z","timestamp":1769072672000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/67\/2\/147\/8430233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,1]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,8,1]]},"published-print":{"date-parts":[[2022,8,1]]}},"URL":"https:\/\/doi.org\/10.1165\/rcmb.2022-0122ed","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8]]},"published":{"date-parts":[[2022,8,1]]},"assertion":[{"value":"2022-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}