{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:32:30Z","timestamp":1791048750071,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":874,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Pneumology Foundation of Comunidad Valenciana"},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["COV20\/01209"],"award-info":[{"award-number":["COV20\/01209"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pneumology Foundation of Comunidad Valenciana"},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["COV20\/01209"],"award-info":[{"award-number":["COV20\/01209"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Beyond the acute infection of coronavirus disease (COVID-19), concern has arisen about long-term effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aim of our study was to analyze if there is any biomarker of fibrogenesis in patients with COVID-19 pneumonia capable of predicting post-COVID-19 pulmonary sequelae. We conducted a multicenter, prospective, observational cohort study of patients admitted to a hospital with bilateral COVID-19 pneumonia. We classified patients into two groups according to severity, and blood sampling to measure matrix metalloproteinase 1 (MMP-1), MMP-7, periostin, and VEGF and respiratory function tests and high-resolution computed tomography were performed at 2 and 12 months after hospital discharge. A total of 135 patients were evaluated at 12 months. Their median age was 61 (interquartile range, 19) years, and 58.5% were men. We found between-group differences in age, radiological involvement, length of hospital stay, and inflammatory laboratory parameters. Differences were found between 2 and 12 months in all functional tests, including improvements in predicted forced vital capacity (98.0% vs. 103.9%; P\u2009=\u20090.001) and Dl \u00a0CO &amp;lt;80% (60.9% vs. 39.7%; P\u2009=\u20090.001). At 12 months, 63% of patients had complete high-resolution computed tomography resolution, but fibrotic changes persisted in 29.4%. Biomarker analysis demonstrated differences at 2 months in periostin (0.8893 vs. 1.437 ng\/ml; P\u2009&amp;lt;\u20090.001) and MMP-7 (8.7249 vs. 15.2181 ng\/ml; P\u2009&amp;lt;\u20090.001). No differences were found at 12 months. In multivariable analysis, only 2-month periostin was associated with 12-month fibrotic changes (odds ratio, 1.0013; 95% confidence interval, 1.0006\u20131.00231; P\u2009=\u20090.003) and 12-month Dl \u00a0CO impairment (odds ratio, 1.0006; 95% confidence interval, 1.0000\u20131.0013; P\u2009=\u20090.047). Our data suggest that early periostin postdischarge could predict the presence of fibrotic pulmonary changes.<\/jats:p>","DOI":"10.1165\/rcmb.2022-0474oc","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T12:58:32Z","timestamp":1677502712000},"page":"321-327","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":23,"title":["Biomarkers of Fibrosis in Patients with COVID-19 One Year After Hospital Discharge: A Prospective Cohort Study"],"prefix":"10.1093","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8842-7054","authenticated-orcid":false,"given":"Alba","family":"Mulet","sequence":"first","affiliation":[{"name":"Pulmonary Department, Hospital Cl\u00ednico, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2304-7779","authenticated-orcid":false,"given":"Julia","family":"Tarras\u00f3","sequence":"additional","affiliation":[{"name":"Pulmonary Department, Hospital Cl\u00ednico, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Rodr\u00edguez-Borja","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Pathology, Hospital Cl\u00ednico de Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Carbonell-Asins","sequence":"additional","affiliation":[{"name":"Bioinformatics and Biostatistics Unit, INCLIVA, University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaia","family":"Lope-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Pathology, Hospital Cl\u00ednico de Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arancha","family":"Mart\u00ed-Martinez","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Pathology, Hospital Cl\u00ednico de Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Murria","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Pathology, Hospital Cl\u00ednico de Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Safont","sequence":"additional","affiliation":[{"name":"Pulmonary Department, Hospital Cl\u00ednico, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estrella","family":"Fernandez-Fabrellas","sequence":"additional","affiliation":[{"name":"Pulmonary Department, Hospital General, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Ros","sequence":"additional","affiliation":[{"name":"Pulmonary Department, Hospital Virgen de la Arrixaca, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Rodriguez-Portal","sequence":"additional","affiliation":[{"name":"Pulmonary Department, Hospital Virgen del Roc\u00edo, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada L.","family":"Andreu","sequence":"additional","affiliation":[{"name":"Pulmonary Department, Hospital los Arcos del Mar Menor, Murcia, Spain; 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