{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:23:50Z","timestamp":1793046230746,"version":"4.5.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":966,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL076139-16"],"award-info":[{"award-number":["T32HL076139-16"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08HL159356"],"award-info":[{"award-number":["K08HL159356"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI135964"],"award-info":[{"award-number":["U19AI135964"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["T32HL076139-16"],"award-info":[{"award-number":["T32HL076139-16"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["K08HL159356"],"award-info":[{"award-number":["K08HL159356"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["U19AI135964"],"award-info":[{"award-number":["U19AI135964"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"DOI":"10.1165\/rcmb.2023-0098ed","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T09:23:51Z","timestamp":1680773031000},"page":"608-609","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":4,"title":["Alveolar Macrophages during Inflammation: A Balancing Act"],"prefix":"10.1093","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2191-5037","authenticated-orcid":false,"given":"Taylor A.","family":"Poor","sequence":"first","affiliation":[{"name":"Department of Medicine Northwestern University Feinberg School of Medicine Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-0518","authenticated-orcid":false,"given":"Luisa","family":"Morales-Nebreda","sequence":"additional","affiliation":[{"name":"Department of Medicine Northwestern University Feinberg School of Medicine Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,1]]},"reference":[{"key":"2026012204092049600_bib1","doi-asserted-by":"crossref","first-page":"16045","DOI":"10.1038\/nrdp.2016.45","article-title":"Sepsis and septic shock","volume":"2","author":"Hotchkiss","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2026012204092049600_bib2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.immuni.2014.04.001","article-title":"Sepsis: current dogma and new perspectives","volume":"40","author":"Deutschman","year":"2014","journal-title":"Immunity"},{"key":"2026012204092049600_bib3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrneph.2017.165","article-title":"Advances in the understanding and treatment of sepsis-induced immunosuppression","volume":"14","author":"Venet","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"2026012204092049600_bib4","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1172\/JCI124615","article-title":"The role of macrophages in the resolution of inflammation","volume":"129","author":"Watanabe","year":"2019","journal-title":"J Clin Invest"},{"key":"2026012204092049600_bib5","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1165\/rcmb.2022-0281OC","article-title":"Pulmonary and non-pulmonary sepsis differentially modulate lung immunity towards secondary bacterial pneumonia: a critical role for alveolar macrophages","volume":"68","author":"Llitjos","year":"2023","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204092049600_bib6","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1084\/jem.20131199","article-title":"Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF","volume":"210","author":"Guilliams","year":"2013","journal-title":"J Exp Med"},{"key":"2026012204092049600_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2012.12.001","article-title":"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis","volume":"38","author":"Yona","year":"2013","journal-title":"Immunity"},{"key":"2026012204092049600_bib8","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1084\/jem.20162152","article-title":"Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span","volume":"214","author":"Misharin","year":"2017","journal-title":"J Exp Med"},{"key":"2026012204092049600_bib9","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1165\/rcmb.2017-0061OC","article-title":"Cell origin dictates programming of resident versus recruited macrophages during acute lung injury","volume":"57","author":"Mould","year":"2017","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204092049600_bib10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41590-020-00845-6","article-title":"Trained immunity, tolerance, priming and differentiation: distinct immunological processes","volume":"22","author":"Divangahi","year":"2021","journal-title":"Nat Immunol"},{"key":"2026012204092049600_bib11","doi-asserted-by":"crossref","first-page":"e140299","DOI":"10.1172\/JCI140299","article-title":"The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging","volume":"131","author":"McQuattie-Pimentel","year":"2021","journal-title":"J Clin Invest"},{"key":"2026012204092049600_bib12","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/s41590-020-0673-x","article-title":"Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis","volume":"21","author":"Roquilly","year":"2020","journal-title":"Nat Immunol"},{"key":"2026012204092049600_bib13","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/j.cell.2018.09.042","article-title":"Induction of autonomous memory alveolar macrophages requires T cell help and is critical to trained immunity","volume":"175","author":"Yao","year":"2018","journal-title":"Cell"},{"key":"2026012204092049600_bib14","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.cell.2014.11.018","article-title":"Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment","volume":"159","author":"Lavin","year":"2014","journal-title":"Cell"},{"key":"2026012204092049600_bib15","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1172\/JCI36498","article-title":"CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury","volume":"119","author":"D\u2019Alessio","year":"2009","journal-title":"J Clin Invest"},{"key":"2026012204092049600_bib16","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.immuni.2018.07.015","article-title":"Regulatory T cells promote macrophage efferocytosis during inflammation resolution","volume":"49","author":"Proto","year":"2018","journal-title":"Immunity"},{"key":"2026012204092049600_bib17","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41577-019-0240-6","article-title":"Efferocytosis in health and disease","volume":"20","author":"Doran","year":"2020","journal-title":"Nat Rev Immunol"}],"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/68\/6\/608\/66313248\/ajrcmb_68_6_608.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/68\/6\/608\/66313248\/ajrcmb_68_6_608.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:15:05Z","timestamp":1769073305000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/68\/6\/608\/8417601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,1]]},"references-count":17,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6,1]]},"published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.1165\/rcmb.2023-0098ed","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6]]},"published":{"date-parts":[[2023,6,1]]},"assertion":[{"value":"2023-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}